{"doi":"10.17615/w76e-ms81","title":"Pretargeted Radioimmunotherapy Using Genetically Engineered Antibody-Streptavidin Fusion Proteins for Treatment of Non-Hodgkin Lymphoma","abstract":"Pretargeted radioimmunotherapy (PRIT) using streptavidin (SAv)-biotin technology can deliver higher therapeutic doses of radioactivity to tumors than conventional RIT. However, “endogenous” biotin can interfere with the effectiveness of this approach by blocking binding of radiolabeled biotin to SAv. We engineered a series of SAv FPs that down-modulate the affinity of SAv for biotin, while retaining high avidity for divalent DOTA-bis-biotin to circumvent this problem.","journal":"UNC Libraries","year":2020,"id":143265,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9547,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":611338,"name":"Amanda Axtman","orcid":null,"position":1,"is_corresponding":false},{"id":611339,"name":"Mark D. Hylarides","orcid":null,"position":2,"is_corresponding":false},{"id":610900,"name":"Jaideep Shenoi","orcid":"0000-0001-8465-3479","position":3,"is_corresponding":false},{"id":611340,"name":"Shani M. Frayo","orcid":null,"position":4,"is_corresponding":false},{"id":536057,"name":"Steven I. Park","orcid":null,"position":5,"is_corresponding":false},{"id":522228,"name":"Ajay K. Gopal","orcid":"0000-0003-3023-6834","position":6,"is_corresponding":false},{"id":374179,"name":"Patrick S. Stayton","orcid":"0000-0001-6939-6371","position":7,"is_corresponding":false},{"id":522227,"name":"Oliver W. Press","orcid":"0000-0002-3147-8037","position":8,"is_corresponding":false},{"id":610901,"name":"Yukang Lin","orcid":"0000-0001-8586-8682","position":9,"is_corresponding":false},{"id":611341,"name":"Nural Orgun","orcid":null,"position":10,"is_corresponding":false},{"id":522226,"name":"Damian J. Green","orcid":"0000-0003-0477-1446","position":11,"is_corresponding":false},{"id":611342,"name":"Franz Buchegger","orcid":null,"position":12,"is_corresponding":false},{"id":444926,"name":"D. Scott Wilbur","orcid":"0000-0001-7767-8731","position":13,"is_corresponding":false},{"id":366214,"name":"John M. Pagel","orcid":"0000-0001-5745-8125","position":14,"is_corresponding":false},{"id":611343,"name":"Aimee L. Kenoyer","orcid":null,"position":15,"is_corresponding":false},{"id":446173,"name":"Donald K. Hamlin","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:17:38.432803Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}