{"doi":"10.17615/w2z2-n825","title":"Matrix metalloproteinase-sensitive thermogelling polymer for bioresponsive local drug delivery","abstract":"Development of a successful bioresponsive drug delivery system requires exquisite engineering of materials so that they are able to respond to the signals stemming from the physiological environment. In this study, we proposed a new Pluronic® based thermogelling system containing matrix metalloproteinase-2 (MMP2) responsive peptide sequences. A novel thermosensitive multiblock copolymer comprising an MMP2-labile octapeptide (Gly-Pro-Val-Gly-Leu-Ile-Gly-Lys) was synthesized from Pluronic® triblock copolymer. The polymer was designed to form thermogel at body temperature and degrade in presence of MMP overexpressed in the tumor. The synthesized polymer was a multiblock copolymer with ~ 2.5 units of Pluronic®. The multiblock copolymer solutions exhibited a reverse thermal gelation around body temperature. The gelation temperatures of the multiblock copolymer solutions were lower than those of the corresponding Pluronic® monomer at a particular concentration. The cytotoxicity of the synthesized polymer was lower comparing to its monomer. The solubility of hydrophobic anticancer drug, paclitaxel, was enhanced in the polymer solutions via micelle formation. The synthesized polymer was preferentially degraded in presence of MMP. Paclitaxel release was dependent on the enzyme concentration. These findings suggest that the synthesized polymer has the potential as controlled drug delivery system due to its unique phase transition and bioresponsive behavior.","journal":"UNC Libraries","year":2020,"id":135426,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9505,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":298045,"name":"Sejin Son","orcid":"0000-0003-1523-2990","position":1,"is_corresponding":false},{"id":273467,"name":"Michael A. Repka","orcid":"0000-0003-2049-4696","position":2,"is_corresponding":false},{"id":592176,"name":"Seongbong Jo","orcid":"0000-0002-9892-5604","position":3,"is_corresponding":false},{"id":592899,"name":"Jin Ki Kim","orcid":null,"position":4,"is_corresponding":false},{"id":592900,"name":"Vivek Kumar Garripelli","orcid":null,"position":5,"is_corresponding":false},{"id":348028,"name":"Won Jong Kim","orcid":"0000-0002-4064-0999","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:16:31.787520Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}