{"doi":"10.17615/w0sf-1351","title":"Rendering Protein-Based Particles Transiently Insoluble for Therapeutic Applications","abstract":"Herein we report the fabrication of protein (bovine serum albumin, BSA) particles which were rendered transiently insoluble using a novel, reductively labile disulfide-based cross-linker. After being cross-linked, the protein particles retain their integrity in aqueous solution and dissolve preferentially under a reducing environment. Our data demonstrates that cleavage of the cross-linker leaves no chemical residue on the reactive amino group. Delivery of a self-replicating RNA was achieved via the transiently insoluble PRINT protein particles. These protein particles can provide new opportunities for drug and gene delivery.","journal":"Figshare","year":2020,"id":141928,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.949,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":608433,"name":"Patrick D. Pohlhaus","orcid":null,"position":1,"is_corresponding":false},{"id":608434,"name":"Bolyn Hubby","orcid":null,"position":2,"is_corresponding":false},{"id":188772,"name":"Jonathan Smith","orcid":null,"position":3,"is_corresponding":false},{"id":372883,"name":"Mary E. Napier","orcid":null,"position":4,"is_corresponding":false},{"id":608435,"name":"Benjamin W. Maynor","orcid":null,"position":5,"is_corresponding":false},{"id":543424,"name":"Ashish Pandya","orcid":null,"position":6,"is_corresponding":false},{"id":541022,"name":"Jing Xu","orcid":"0000-0001-7184-8330","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:17:27.861239Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}