{"doi":"10.17615/vypv-4b94","title":"Targeting the interaction between RNA-binding protein HuR and FOXQ1 suppresses breast cancer invasion and metastasis","abstract":"Patients diagnosed with metastatic breast cancer have a dismal 5-year survival rate of only 24%. The RNA-binding protein Hu antigen R (HuR) is upregulated in breast cancer, and elevated cytoplasmic HuR correlates with high-grade tumors and poor clinical outcome of breast cancer. HuR promotes tumorigenesis by regulating numerous proto-oncogenes, growth factors, and cytokines that support major tumor hallmarks including invasion and metastasis. Here, we report a HuR inhibitor KH-3, which potently suppresses breast cancer cell growth and invasion. Furthermore, KH-3 inhibits breast cancer experimental lung metastasis, improves mouse survival, and reduces orthotopic tumor growth. Mechanistically, we identify FOXQ1 as a direct target of HuR. KH-3 disrupts HuR–FOXQ1 mRNA interaction, leading to inhibition of breast cancer invasion. Our study suggests that inhibiting HuR is a promising therapeutic strategy for lethal metastatic breast cancer.","journal":"UNC Libraries","year":2022,"id":292041,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9507,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":976192,"name":"C. Zhong","orcid":null,"position":1,"is_corresponding":false},{"id":976193,"name":"J. Karanicolas","orcid":null,"position":2,"is_corresponding":false},{"id":976194,"name":"F.P. Gao","orcid":null,"position":3,"is_corresponding":false},{"id":976195,"name":"L. Lan","orcid":null,"position":4,"is_corresponding":false},{"id":10720,"name":"X. Wu","orcid":"0000-0001-7655-389X","position":5,"is_corresponding":false},{"id":976196,"name":"M. Ji","orcid":null,"position":6,"is_corresponding":false},{"id":976197,"name":"R. Gowthaman","orcid":null,"position":7,"is_corresponding":false},{"id":976198,"name":"Lianglu Wei","orcid":null,"position":8,"is_corresponding":false},{"id":27134,"name":"L. Xu","orcid":"0000-0001-8997-3199","position":9,"is_corresponding":false},{"id":976199,"name":"R.T. Marquez","orcid":null,"position":10,"is_corresponding":false},{"id":26078,"name":"S. Han","orcid":"0000-0001-8383-7348","position":11,"is_corresponding":false},{"id":1874,"name":"L. Li","orcid":"0000-0001-6411-6107","position":12,"is_corresponding":false},{"id":976200,"name":"D.R. Welch","orcid":null,"position":13,"is_corresponding":false},{"id":976201,"name":"G. Gardashova","orcid":null,"position":14,"is_corresponding":false},{"id":976202,"name":"D.A. Dixon","orcid":null,"position":15,"is_corresponding":false},{"id":141746,"name":"S. Roy","orcid":null,"position":16,"is_corresponding":false},{"id":945840,"name":"J. Aubé","orcid":null,"position":17,"is_corresponding":false},{"id":976191,"name":"S. Wood","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T00:30:42.221508Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}