{"doi":"10.17615/vrs4-sd31","title":"Higher macrophage inflammatory protein (MIP)-1α and MIP-1β levels from CD8+ T cells are associated with asymptomatic HIV-1 infection","abstract":"To test the hypothesis that β-chemokine levels may be relevant to the control of HIV in vivo, we compared RANTES, MIP-1α, and MIP-1β production from purified CD8+ T cells from 81 HIV-infected subjects and from 28 uninfected donors. Asymptomatic HIV+ subjects produced significantly higher levels of MIP-1α and MIP-1β, but not RANTES, than uninfected donors or patients that progressed to AIDS. In contrast, β chemokines in plasma were either nondetectable or showed no correlation with clinical status. The high β-chemokine-mediated anti-HIV activity was against the macrophage tropic isolate HIV-1(BAL), with no demonstrable effect on the replication of the T-cell tropic HIV-1(IIIB). These findings suggest that constitutive β-chemokine production may play an important role in the outcome of HIV-1 infection.","journal":"UNC Libraries","year":2020,"id":126017,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9649,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":573431,"name":"F. Cocchi","orcid":null,"position":1,"is_corresponding":false},{"id":573432,"name":"A.L. DeVico","orcid":null,"position":2,"is_corresponding":false},{"id":573433,"name":"R. Redfield","orcid":null,"position":3,"is_corresponding":false},{"id":533801,"name":"D. Margolis","orcid":null,"position":4,"is_corresponding":false},{"id":573434,"name":"W.A. Blattner","orcid":null,"position":5,"is_corresponding":false},{"id":573435,"name":"R.C. Gallo","orcid":null,"position":6,"is_corresponding":false},{"id":573436,"name":"A. Garzino-Demo","orcid":null,"position":7,"is_corresponding":false},{"id":573437,"name":"S. Colombini-Hatch","orcid":null,"position":8,"is_corresponding":false},{"id":573438,"name":"R. Yarchoan","orcid":null,"position":9,"is_corresponding":false},{"id":573430,"name":"F. Cleghorn","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:15:19.482428Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}