{"doi":"10.17615/vnkv-3029","title":"Intimate partner violence and oral HIV pre-exposure prophylaxis adherence among young African women","abstract":"Objective: To estimate the effect of intimate partner violence (IPV) on oral pre-exposure prophylaxis (PrEP) adherence among adolescent girls and young women (AGYW). Design: We conducted a secondary analysis of data from HIV Prevention Trials Network 082 (HPTN 082), a multisite prospective study designed to assess oral PrEP adherence among AGYW in southern Africa. Methods: We estimated the relative prevalence of high PrEP adherence 3 and 6 months after initiation among AGYW 16 – 25 years who reported a history of any IPV in the past year at enrollment versus AGYW who did not, both overall and by age. High adherence was defined as an intracellular tenofovir-diphosphate concentration at least 700 fmol/ punch or more dried blood spots. Results: Among 409 PrEP-initiating AGYW, half (49%) reported experiencing any IPV by a current/recent partner in the year prior to enrollment. Overall, a similar proportion of AGYW who reported IPV had high PrEP adherence at months 3 and 6 as AGYW who did not report IPV. There was, however, evidence of effect modification by age at month 3: among AGYW less than 21 years old, those who reported IPV were less than half as likely to have high adherence [adjusted PR (aPR) = 0.43, 95% confidence interval (CI) 0.22– 0.86]; among AGYW aged 21 years or older, those who reported IPV were more than twice as likely to have high adherence (aPR = 2.21, 95% CI 1.34– 3.66). At month 6, effect estimates within each age stratum were consistent in direction to those at month 3. Conclusion: IPV events may either impede or motivate PrEP adherence among African AGYW, with age appearing to be an important consideration for IPV-related adherence interventions.","journal":"UNC Libraries","year":2024,"id":499175,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9147,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1347129,"name":"S. Hosek","orcid":null,"position":1,"is_corresponding":false},{"id":403337,"name":"A. Pettifor","orcid":null,"position":2,"is_corresponding":false},{"id":598083,"name":"S. Delany-Moretlwe","orcid":null,"position":3,"is_corresponding":false},{"id":273592,"name":"Linda‐Gail Bekker","orcid":"0000-0002-0755-4386","position":4,"is_corresponding":false},{"id":1347130,"name":"C. Celum","orcid":null,"position":5,"is_corresponding":false},{"id":35728,"name":"B.W Pence","orcid":null,"position":6,"is_corresponding":false},{"id":590950,"name":"D. Giovenco","orcid":null,"position":7,"is_corresponding":false},{"id":413426,"name":"Lisa Hightow‐Weidman","orcid":"0000-0002-2421-923X","position":8,"is_corresponding":false},{"id":591009,"name":"K.A. Powers","orcid":null,"position":9,"is_corresponding":false},{"id":385787,"name":"Nyaradzo Mgodi","orcid":"0000-0002-3085-5259","position":10,"is_corresponding":false},{"id":1198068,"name":"D. Donnell","orcid":null,"position":11,"is_corresponding":false},{"id":1347128,"name":"Poetry Anderson","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T02:09:45.971055Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}