{"doi":"10.17615/vkh7-vd78","title":"Misclassification of Drug Failures in Plasmodium falciparum Clinical Trials in Southeast Asia","abstract":"Most trials of antimalarials occur in areas where reinfections are possible. For Plasmodium falciparum, reinfections are distinguished from recrudescences by PCR analysis of 3 polymorphic genes. However, the validity of this approach has never been rigorously tested. We tested for misclassification in 6 patients from clinical trials in Thailand and Cambodia who were classified as reinfected by the standard PCR protocol. Using heteroduplex tracking assays and direct DNA sequencing, we found that 5 of 6 (83%) patients were misclassified. Misclassification in this manner overestimates the efficacy of antimalarials and delays recognition of decreasing therapeutic efficacy, thus delaying potential policy changes.","journal":"UNC Libraries","year":2020,"id":141492,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.954,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":270632,"name":"Jonathan J. Juliano","orcid":"0000-0002-0591-0850","position":1,"is_corresponding":false},{"id":607531,"name":"Sornchai Looareesuwan","orcid":null,"position":2,"is_corresponding":false},{"id":606986,"name":"Noppadon Tangpukdee","orcid":"0000-0002-4551-6268","position":3,"is_corresponding":false},{"id":107755,"name":"Frédéric Ariey","orcid":"0000-0002-0680-1090","position":4,"is_corresponding":false},{"id":536064,"name":"Chansuda Wongsrichanalai","orcid":null,"position":5,"is_corresponding":false},{"id":606987,"name":"Carol Booth Olson","orcid":"0000-0003-2034-9421","position":6,"is_corresponding":false},{"id":536065,"name":"William O. Rogers","orcid":null,"position":7,"is_corresponding":false},{"id":607532,"name":"Srivicha Krudsood","orcid":null,"position":8,"is_corresponding":false},{"id":272760,"name":"Steven R. Meshnick","orcid":null,"position":9,"is_corresponding":false},{"id":536069,"name":"Rithy Sem","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:17:24.429854Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}