{"doi":"10.17615/vj08-2d58","title":"GWAS for Interleukin-1β levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation","abstract":"There is no agnostic GWAS evidence for the genetic control of IL-1β expression in periodontal disease. Here we report a GWAS for “high” gingival crevicular fluid IL-1β expression among 4910 European-American adults and identify association signals in the IL37 locus. rs3811046 at this locus (p = 3.3 × 10−22) is associated with severe chronic periodontitis (OR = 1.50; 95% CI = 1.12–2.00), 10-year incident tooth loss (≥3 teeth: RR = 1.33; 95% CI = 1.09–1.62) and aggressive periodontitis (OR = 1.12; 95% CI = 1.01–1.26) in an independent sample of 4927 German/Dutch adults. The minor allele at rs3811046 is associated with increased expression of IL-1β in periodontal tissue. In RAW macrophages, PBMCs and transgenic mice, the IL37 variant increases expression of IL-1β and IL-6, inducing more severe periodontal disease, while IL-37 protein production is impaired and shows reduced cleavage by caspase-1. A second variant in the IL37 locus (rs2708943, p = 4.2 × 10−7) associates with attenuated IL37 mRNA expression. Overall, we demonstrate that IL37 variants modulate the inflammatory cascade in periodontal disease.","journal":"UNC Libraries","year":2024,"id":499110,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9521,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1346179,"name":"Jing Li","orcid":"0000-0003-3209-8973","position":1,"is_corresponding":false},{"id":526071,"name":"K.E. North","orcid":null,"position":2,"is_corresponding":false},{"id":595089,"name":"William T. Seaman","orcid":null,"position":3,"is_corresponding":false},{"id":526075,"name":"J.D. Beck","orcid":null,"position":4,"is_corresponding":false},{"id":526072,"name":"S. Offenbacher","orcid":null,"position":5,"is_corresponding":false},{"id":608858,"name":"Arne S. Schäefer","orcid":"0000-0001-5816-6765","position":6,"is_corresponding":false},{"id":373874,"name":"Dale O. Cowley","orcid":"0000-0001-5697-5817","position":7,"is_corresponding":false},{"id":624252,"name":"Cary S. Agler","orcid":"0000-0002-5510-7214","position":8,"is_corresponding":false},{"id":512121,"name":"Yue Jiao","orcid":"0000-0002-5705-9789","position":9,"is_corresponding":false},{"id":812590,"name":"L. Sun","orcid":"0009-0002-0616-069X","position":10,"is_corresponding":false},{"id":593751,"name":"S.P. Barros","orcid":null,"position":11,"is_corresponding":false},{"id":27181,"name":"S. Zhang","orcid":"0000-0002-8480-2662","position":12,"is_corresponding":false},{"id":601214,"name":"S.J. Kim","orcid":null,"position":13,"is_corresponding":false},{"id":549509,"name":"K. Divaris","orcid":null,"position":14,"is_corresponding":false},{"id":1005887,"name":"J.T. Marchesan","orcid":null,"position":15,"is_corresponding":false},{"id":512338,"name":"Sompop Bencharit","orcid":"0000-0003-3715-8971","position":16,"is_corresponding":false},{"id":1005888,"name":"T. Morelli","orcid":null,"position":17,"is_corresponding":false},{"id":408812,"name":"Matthias Munz","orcid":"0000-0002-4728-3357","position":18,"is_corresponding":false},{"id":292344,"name":"Kevin Moss","orcid":"0000-0003-2332-1774","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T02:09:45.971055Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}