{"doi":"10.17615/v11x-0v76","title":"Sex-Specific Prediction Models for Sleep Apnea From the Hispanic Community Health Study/Study of Latinos","abstract":"OBJECTIVE: We developed and validated the first-ever sleep apnea (SA) risk calculator in a large population-based cohort of Hispanic/Latino subjects. METHODS: Cross-sectional data on adults from the Hispanic Community Health Study/Study of Latinos (2008-2011) were analyzed. Subjective and objective sleep measurements were obtained. Clinically significant SA was defined as an apnea-hypopnea index ≥ 15 events per hour. Using logistic regression, four prediction models were created: three sex-specific models (female-only, male-only, and a sex × covariate interaction model to allow differential predictor effects), and one overall model with sex included as a main effect only. Models underwent 10-fold cross-validation and were assessed by using the C statistic. SA and its predictive variables; a total of 17 variables were considered. RESULTS: A total of 12,158 participants had complete sleep data available; 7,363 (61%) were women. The population-weighted prevalence of SA (apnea-hypopnea index ≥ 15 events per hour) was 6.1% in female subjects and 13.5% in male subjects. Male-only (C statistic, 0.808) and female-only (C statistic, 0.836) prediction models had the same predictor variables (ie, age, BMI, self-reported snoring). The sex-interaction model (C statistic, 0.836) contained sex, age, age × sex, BMI, BMI × sex, and self-reported snoring. The final overall model (C statistic, 0.832) contained age, BMI, snoring, and sex. We developed two websites for our SA risk calculator: one in English (https://www.montefiore.org/sleepapneariskcalc.html) and another in Spanish (http://www.montefiore.org/sleepapneariskcalc-es.html). CONCLUSIONS: We created an internally validated, highly discriminating, well-calibrated, and parsimonious prediction model for SA. Contrary to the study hypothesis, the variables did not have different predictive magnitudes in male and female subjects.","journal":"UNC Libraries","year":2020,"id":138161,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":0.0,"corpus_rank":10062,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.554,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":312684,"name":"Martica H. Hall","orcid":"0000-0003-0642-2098","position":1,"is_corresponding":false},{"id":465646,"name":"H. Klar Yaggi","orcid":"0000-0002-9888-2480","position":2,"is_corresponding":false},{"id":368853,"name":"David B. Hanna","orcid":"0000-0002-1985-9865","position":3,"is_corresponding":false},{"id":427001,"name":"Daniela Sotres‐Alvarez","orcid":"0000-0002-3226-6140","position":4,"is_corresponding":false},{"id":322828,"name":"Phyllis C. Zee","orcid":"0000-0001-6296-6685","position":5,"is_corresponding":false},{"id":594261,"name":"Yanping Teng","orcid":null,"position":6,"is_corresponding":false},{"id":21964,"name":"Robert C. Kaplan","orcid":"0000-0003-1571-4615","position":7,"is_corresponding":false},{"id":600104,"name":"José S. Loredo","orcid":null,"position":8,"is_corresponding":false},{"id":17008,"name":"Susan Redline","orcid":"0000-0002-6585-1610","position":9,"is_corresponding":false},{"id":593537,"name":"Neomi Shah","orcid":"0009-0003-5804-0507","position":10,"is_corresponding":false},{"id":371306,"name":"Mimi S. Kim","orcid":"0000-0002-6266-3569","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:17:02.849477Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}