{"doi":"10.17615/ty8n-2k84","title":"Higher Branched-Chain Amino Acid Intake Is Associated with a Lower Prevalence of Being Overweight or Obese in Middle-Aged East Asian and Western Adults","abstract":"Beneficial effects on body weight of supplementation with BCAA, including leucine, isoleucine, and valine, have been observed in animal and human studies. However, population-based studies on dietary BCAA intake and body weight are lacking. The objective of this study was to examine the association between dietary BCAA intake and risk of overweight status/obesity among multi-ethnic populations. The International Study of Macro-/Micronutrients and Blood Pressure is a cross-sectional epidemiological investigation in China, Japan, the UK, and the US. The study cohort included 4429 men and women ages 40–59 y who were free of diabetes. Diet was assessed by 4 multi-pass 24-h recalls; data on nutrients including BCAA were derived from country-specific food tables. Overweight status and obesity were defined as BMI ≥ 25 and BMI ≥ 30 kg/m2, respectively. Multivariable-adjusted OR of overweight status/obesity and 95% CI by quartiles of BCAA intake were estimated by logistic regression. Mean BCAA intake was 2.6 ± 0.6% energy; intake was significantly lower among Chinese participants and similar among participants from the other 3 countries. Compared with those in the first quartile, the multivariable-adjusted OR (95% CI) of overweight status from the 2nd to 4th quartiles of BCAA intake were 0.97 (0.80–1.17), 0.91 (0.75–1.11), and 0.70 (0.57–0.86), respectively (P-trend < 0.01). BCAA intake and obesity were also inversely associated (P-trend = 0.03). In conclusion, higher dietary BCAA intake is associated with lower prevalence of overweight status/obesity among apparently healthy middle-aged adults from East Asian and Western countries.","journal":"UNC Libraries","year":2020,"id":107824,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9543,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":353720,"name":"Pengcheng Xun","orcid":"0000-0002-6245-4505","position":1,"is_corresponding":false},{"id":37777,"name":"Jeremiah Stamler","orcid":null,"position":2,"is_corresponding":false},{"id":37779,"name":"Martha L. Daviglus","orcid":"0000-0002-6791-8727","position":3,"is_corresponding":false},{"id":37775,"name":"Linda Van Horn","orcid":"0000-0002-1362-5806","position":4,"is_corresponding":false},{"id":173667,"name":"Li-Qiang Qin","orcid":"0000-0002-5231-2562","position":5,"is_corresponding":false},{"id":370818,"name":"Ka He","orcid":"0000-0003-2792-0184","position":6,"is_corresponding":false},{"id":517627,"name":"Deborah Bujnowski","orcid":"0000-0002-3485-7673","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:12:39.385256Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}