{"doi":"10.17615/tqhm-j252","title":"Dual self-regulated delivery of insulin and glucagon by a hybrid patch","abstract":"Reduced β-cell function and insulin deficiency are hallmarks of diabetes mellitus, which is often accompanied by the malfunction of glucagon-secreting α-cells. While insulin therapy has been developed to treat insulin deficiency, the on-demand supplementation of glucagon for acute hypoglycemia treatment remains inadequate. Here, we describe a transdermal patch that mimics the inherent counterregulatory effects of β-cells and α-cells for blood glucose management by dynamically releasing insulin or glucagon. The two modules share a copolymerized matrix but comprise different ratios of the key monomers to be \"dually responsive\" to both hyper- and hypoglycemic conditions. In a type 1 diabetic mouse model, the hybrid patch effectively controls hyperglycemia while minimizing the occurrence of hypoglycemia in the setting of insulin therapy with simulated delayed meal or insulin overdose.","journal":"UNC Libraries","year":2024,"id":499676,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.951,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1347616,"name":"Zhongping Gu","orcid":"0000-0002-3564-0943","position":1,"is_corresponding":false},{"id":1348578,"name":"Zhuyun Wang","orcid":null,"position":2,"is_corresponding":false},{"id":1347617,"name":"Huai Li","orcid":"0000-0001-7129-6660","position":3,"is_corresponding":false},{"id":1348579,"name":"Wu V","orcid":null,"position":4,"is_corresponding":false},{"id":1345802,"name":"Kahkoska A.R","orcid":null,"position":5,"is_corresponding":false},{"id":1325773,"name":"Yang Zeng","orcid":"0000-0002-4462-9711","position":6,"is_corresponding":false},{"id":1348580,"name":"Miedema J.R","orcid":null,"position":7,"is_corresponding":false},{"id":1347618,"name":"Jihua Yu","orcid":"0000-0001-5849-7636","position":8,"is_corresponding":false},{"id":1348257,"name":"Wen D","orcid":null,"position":9,"is_corresponding":false},{"id":1312341,"name":"Buse J.B","orcid":null,"position":10,"is_corresponding":false},{"id":340544,"name":"Guanhua Chen","orcid":"0000-0002-9314-2037","position":11,"is_corresponding":false},{"id":1347615,"name":"Jiwen Wang","orcid":"0000-0001-8568-7654","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T02:09:53.188165Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}