{"doi":"10.17615/tb76-8r77","title":"Dengue virus envelope protein domain I/II hinge determines long-lived serotype-specific dengue immunity","abstract":"Dengue virus is the most important arthropod-borne viral disease of humans worldwide, with an estimated 390 million acute infections annually. The best means to control this global health threat is a vaccine, but dengue vaccine development has progressed slowly, partly because the antigenic targets required to stimulate long-term immunity are not well-defined. Here, we show a specific region on the viral surface (the envelope domain I/II hinge) that is the target of protective antibodies after primary human infections. These results are critically important for dengue vaccine design, because we hypothesize that a successful dengue vaccine will stimulate antibodies that target this region. More broadly, this study establishes a template for similar approaches for improving vaccines for influenza, HIV, hepatitis C virus, and other clinically important viral pathogens.","journal":"UNC Libraries","year":2021,"id":211526,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9548,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":533155,"name":"Kristen M. Kahle","orcid":"0000-0002-9210-0249","position":1,"is_corresponding":false},{"id":594112,"name":"Jennifer M. Pfaff","orcid":null,"position":2,"is_corresponding":false},{"id":103776,"name":"Aravinda M. de Silva","orcid":null,"position":3,"is_corresponding":false},{"id":5952,"name":"Ralph S. Baric","orcid":"0000-0001-6827-8701","position":4,"is_corresponding":false},{"id":106531,"name":"James E. Crowe","orcid":"0000-0002-0049-1079","position":5,"is_corresponding":false},{"id":547191,"name":"Ruklanthi de Alwis","orcid":"0000-0002-2319-3701","position":6,"is_corresponding":false},{"id":105503,"name":"Boyd L. Yount","orcid":"0000-0002-6099-8429","position":7,"is_corresponding":false},{"id":533821,"name":"Jeremy Huynh","orcid":null,"position":8,"is_corresponding":false},{"id":388360,"name":"Scott A. Smith","orcid":"0000-0002-2143-2342","position":9,"is_corresponding":false},{"id":510297,"name":"Carlos A. Sariol","orcid":"0000-0001-7535-4303","position":10,"is_corresponding":false},{"id":355497,"name":"Laura White","orcid":"0000-0002-1859-4981","position":11,"is_corresponding":false},{"id":283938,"name":"Benjamin J. Doranz","orcid":"0000-0002-8245-3083","position":12,"is_corresponding":false},{"id":599971,"name":"Scott R. Royal","orcid":"0000-0001-5724-0644","position":13,"is_corresponding":false},{"id":279586,"name":"William B. Messer","orcid":"0000-0002-4381-6347","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:52:20.112538Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}