{"doi":"10.17615/t4vg-d904","title":"Asymmetric bias in user guided segmentations of brain structures","abstract":"Brain morphometric studies often incorporate comparative hemispheric asymmetry analyses of segmented brain structures. In this work, we present evidence that common user guided structural segmentation techniques exhibit strong left-right asymmetric biases and thus fundamentally influence any left-right asymmetry analyses. In this study, MRI scans from ten pediatric subjects were employed for studying segmentations of amygdala, globus pallidus, putamen, caudate, and lateral ventricle. Additionally, two pediatric and three adult scans were used for studying hippocampus segmentation. Segmentations of the sub-cortical structures were performed by skilled raters using standard manual and semi-automated methods. The left-right mirrored versions of each image were included in the data and segmented in a random order to assess potential left-right asymmetric bias. Using shape analysis we further assessed whether the asymmetric bias is consistent across subjects and raters with the focus on the hippocampus.","journal":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","year":2020,"id":136991,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.954,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":418452,"name":"Sarah J. Peterson","orcid":"0000-0002-4821-5196","position":1,"is_corresponding":false},{"id":596850,"name":"Michael M. Graves","orcid":null,"position":2,"is_corresponding":false},{"id":266784,"name":"Beatriz Paniagua","orcid":"0000-0002-8437-6632","position":3,"is_corresponding":false},{"id":332286,"name":"Heather C. Hazlett","orcid":"0000-0001-9166-1434","position":4,"is_corresponding":false},{"id":596851,"name":"Kshamta Bhatt","orcid":null,"position":5,"is_corresponding":false},{"id":104453,"name":"Matthew W. Mosconi","orcid":"0000-0002-1981-6777","position":6,"is_corresponding":false},{"id":266786,"name":"Martin Styner","orcid":"0000-0002-8747-5118","position":7,"is_corresponding":false},{"id":596186,"name":"Joseph Blocher","orcid":"0000-0002-4618-9158","position":8,"is_corresponding":false},{"id":594062,"name":"Rachel G. Smith","orcid":null,"position":9,"is_corresponding":false},{"id":596187,"name":"Mohammed Elsayed","orcid":"0000-0001-7523-3405","position":10,"is_corresponding":false},{"id":596188,"name":"Scott R. White","orcid":"0000-0002-0831-9097","position":11,"is_corresponding":false},{"id":406981,"name":"Eric Maltbie","orcid":"0000-0003-2489-9674","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:16:52.487376Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}