{"doi":"10.17615/synn-ff29","title":"CalDAG-GEFI Deficiency Reduces Atherosclerotic Lesion Development in MiceSignificance","abstract":"Platelets are important to the development and progression of atherosclerotic lesions. However, relatively little is known about the contribution of platelet signaling to this pathological process. Our recent work identified two independent, yet synergistic signaling pathways that lead to the activation of the small GTPase Rap1; one mediated by the guanine nucleotide exchange factor, CalDAG-GEFI (CDGI), the other by P2Y12, a platelet receptor for ADP and the target of anti-platelet drugs. In this study, we evaluated lesion formation in atherosclerosis-prone low-density lipoprotein receptor deficient (Ldlr−/−) mice lacking CDGI and/or P2Y12 in hematopoietic cells.","journal":"UNC Libraries","year":2020,"id":142363,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9489,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":348071,"name":"Robert H. Lee","orcid":"0000-0001-9871-0593","position":1,"is_corresponding":false},{"id":243111,"name":"Nigel Mackman","orcid":"0000-0002-9170-7700","position":2,"is_corresponding":false},{"id":434654,"name":"A. Phillip Owens","orcid":"0000-0002-0835-620X","position":3,"is_corresponding":false},{"id":609454,"name":"Ashley L. Beale","orcid":null,"position":4,"is_corresponding":false},{"id":342594,"name":"Pamela B. Conley","orcid":"0000-0001-9400-6531","position":5,"is_corresponding":false},{"id":471256,"name":"Caterina Casari","orcid":"0000-0002-8271-6795","position":6,"is_corresponding":false},{"id":594282,"name":"Raymond Piatt","orcid":null,"position":7,"is_corresponding":false},{"id":288434,"name":"David S. Paul","orcid":"0000-0001-6686-8134","position":8,"is_corresponding":false},{"id":288440,"name":"Wolfgang Bergmeier","orcid":"0000-0002-1211-8861","position":9,"is_corresponding":false},{"id":348070,"name":"Yacine Boulaftali","orcid":"0000-0003-4870-2098","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:17:31.424593Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}