{"doi":"10.17615/sxpb-g506","title":"Regulation of the hTERT telomerase catalytic subunit by the c-Abl tyrosine kinase","abstract":"BACKGROUND: Telomeres consist of repetitive (TTAGGG) DNA sequences that are maintained by the multisubunit telomerase ribonucleoprotein. Telomerase consists of an RNA, which serves as template for the sequence tracts, and a catalytic subunit that functions in reverse transcription of the RNA template. Cloning and characterization of the human catalytic subunit of telomerase (hTERT) has supported a role in cell transformation. How telomerase activity is regulated, however, is largely unknown. RESULTS: We show here that hTERT associates directly with the c-Abl protein tyrosine kinase. We also found that c-Abl phosphorylates hTERT and inhibits hTERT activity. Moreover, our findings demonstrate that exposure of cells to ionizing radiation induces tyrosine phosphorylation of hTERT by a c-Abl-dependent mechanism. The functional significance of the c-Abl-hTERT interaction is supported by the demonstration that cells deficient in c-Abl show telomere lengthening. CONCLUSIONS: The ubiquitously expressed c-Abl tyrosine kinase is activated by DNA double-strand breaks. Our finding of telomere lengthening in c-Abl-deficient cells and the functional interactions between c-Abl and hTERT support a role for c-Abl in the regulation of telomerase function.","journal":"UNC Libraries","year":2021,"id":205651,"datarank":0.3453877639491069,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.0,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9645,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":789474,"name":"P. Pandey","orcid":null,"position":1,"is_corresponding":false},{"id":789475,"name":"Y. Whang","orcid":null,"position":2,"is_corresponding":false},{"id":789476,"name":"Z-M Yuan","orcid":null,"position":3,"is_corresponding":false},{"id":789477,"name":"Diana Weaver","orcid":null,"position":4,"is_corresponding":false},{"id":789478,"name":"S. Dhar","orcid":null,"position":5,"is_corresponding":false},{"id":46398,"name":"V. Kumar","orcid":"0009-0000-9790-664X","position":6,"is_corresponding":false},{"id":789479,"name":"S. Kharbanda","orcid":null,"position":7,"is_corresponding":false},{"id":789480,"name":"D. Kufe","orcid":null,"position":8,"is_corresponding":false},{"id":789481,"name":"P. Majumder","orcid":null,"position":9,"is_corresponding":false},{"id":789482,"name":"W. Strauss","orcid":null,"position":10,"is_corresponding":false},{"id":789483,"name":"T.K. Pandita","orcid":null,"position":11,"is_corresponding":false},{"id":483635,"name":"C. Chen","orcid":"0000-0001-9159-4489","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:51:33.996102Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}