{"doi":"10.17615/shsq-m884","title":"Genetic determinants of BMI from early childhood to adolescence: the Santiago Longitudinal Study","abstract":"Background: While the genetic contribution to obesity is well established, few studies have examined how genetic variants influence standardized body mass index Z-score (BMIz) in Hispanics/Latinos, especially across childhood and adolescence. Objectives: We estimated the effect of established BMIz loci in Chilean children of the Santiago Longitudinal Study (SLS). Methods: We examined associations with BMIz at age 10 for 15 loci previously identified in European children. For significant loci, we performed association analyses at ages 5 and 16 years, for which we have smaller sample sizes. We tested associations of unweighted genetic risk scores (GRSs) for previously identified tag variants (GRS_EUR) and from the most significant variants in SLS at each locus (GRS_SLS). Results: We generalized five variants at age 10 (P < 0.05 and directionally consistent), including rs543874 that reached Bonferroni-corrected significance. The effect on BMIz was greatest at age 10 for all significant loci, except FTO, which exhibited an increase in effect from ages 5 to 16. Both GRSs were associated with BMIz (P < 0.0001), but GRS_SLS explained a much greater proportion of the variation (13.63%). Conclusion: Our results underscore the importance of conducting genetic investigations across life stages and selecting ancestry appropriate tag variants in future studies for disease prediction and clinical evaluation.","journal":"UNC Libraries","year":2024,"id":499054,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8712,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":385448,"name":"Betsy Lozoff","orcid":"0000-0002-0399-582X","position":1,"is_corresponding":false},{"id":543410,"name":"M. Graff","orcid":null,"position":2,"is_corresponding":false},{"id":573664,"name":"Y. Wang","orcid":"0000-0001-9849-0682","position":3,"is_corresponding":false},{"id":520754,"name":"Cecilia Albala","orcid":"0000-0002-6135-334X","position":4,"is_corresponding":false},{"id":385445,"name":"Sheila Gahagan","orcid":"0000-0002-1105-7323","position":5,"is_corresponding":false},{"id":380798,"name":"Geetha Chittoor","orcid":"0000-0001-6443-6012","position":6,"is_corresponding":false},{"id":520755,"name":"Bárbara Ángel","orcid":"0000-0001-8773-5904","position":7,"is_corresponding":false},{"id":385447,"name":"Estela Blanco","orcid":"0000-0002-6232-9210","position":8,"is_corresponding":false},{"id":385449,"name":"V. Saroja Voruganti","orcid":"0000-0002-8704-4529","position":9,"is_corresponding":false},{"id":526071,"name":"K.E. North","orcid":null,"position":10,"is_corresponding":false},{"id":267375,"name":"José Luis Santos","orcid":"0000-0003-2895-0369","position":11,"is_corresponding":false},{"id":21701,"name":"Anne E. Justice","orcid":"0000-0002-8903-8712","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:09:45.971055Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}