{"doi":"10.17615/shas-p528","title":"The Relationship of Duffy Gene Polymorphism with High-Sensitivity C-Reactive Protein, Mortality, and Cardiovascular Outcomes in Black Individuals","abstract":"Background: Black adults have higher incidence of all-cause mortality and worse cardiovascular disease (CVD) outcomes when compared to other U.S. populations. The Duffy chemokine receptor is not expressed on erythrocytes in a large majority of Black adults, but the clinical implications of this are unclear. Methods: Here, we investigated the relationship of Duffy receptor status, high-sensitivity C-reactive protein (hs-CRP), and mortality and incident CVD events (coronary heart disease, stroke, and heart failure) in self-identified Black members of three contemporary, longitudinal cohort studies (the Women’s Health Initiative, Jackson Heart Study, and Multi-Ethnic Study of Atherosclerosis). Data on 14,358 Black participants (9023 Duffy-null and 5335 Duffy-receptor-positive, as defined using single-nucleotide polymorphism (SNP) rs2814778) were included in this analysis. Results: Duffy null was strongly associated with higher hs-CRP (meta-analysis p = 2.62 × 10−9), but the association was largely attenuated, though still marginally significant (p = 0.005), after conditioning on known CRP locus alleles in linkage disequilibrium with the Duffy gene. In our discovery cohorts, Duffy-null status appeared to be associated with a higher risk of all-cause mortality and incident stroke, though these associations were attenuated and non-significant following adjustment for traditional risk factors including hs-CRP. Moreover, the association of Duffy-null status with mortality could not be replicated in an independent sample of Black adults from the UK Biobank. Conclusions: These findings suggest that the higher levels of hs-CRP found in Duffy-null individuals may be in part independent of CRP alleles known to influence circulating levels of hs-CRP. During the follow-up of this community-based sample of Black participants, Duffy-null status was not associated with mortality or incident CVD events independently of traditional risk factors including hs-CRP.","journal":"UNC Libraries","year":2024,"id":505724,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.96,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1310511,"name":"Bjoernar Tuftin","orcid":"0009-0001-6486-3708","position":1,"is_corresponding":false},{"id":364352,"name":"Stephen J. Peterson","orcid":"0000-0002-6847-3969","position":2,"is_corresponding":false},{"id":11262,"name":"Laura M. Raffield","orcid":"0000-0002-7892-193X","position":3,"is_corresponding":false},{"id":48174,"name":"KARL T. KELSEY","orcid":"0000-0002-2302-1600","position":4,"is_corresponding":false},{"id":1310928,"name":"Manish A. Parikh","orcid":null,"position":5,"is_corresponding":false},{"id":969234,"name":"Matthew S. Briggs","orcid":"0000-0002-0831-7614","position":6,"is_corresponding":false},{"id":967478,"name":"Edward T. Ha","orcid":"0000-0003-4904-0049","position":7,"is_corresponding":false},{"id":236910,"name":"Kent D. Taylor","orcid":"0000-0002-2756-4370","position":8,"is_corresponding":false},{"id":25010,"name":"Alex P. Reiner","orcid":"0000-0002-1427-4470","position":9,"is_corresponding":false},{"id":24935,"name":"Wendy S. Post","orcid":"0000-0002-8655-5204","position":10,"is_corresponding":false},{"id":461732,"name":"Usman A. Tahir","orcid":"0000-0002-3657-6082","position":11,"is_corresponding":false},{"id":57638,"name":"April P. Carson","orcid":"0000-0002-7970-6756","position":12,"is_corresponding":false},{"id":11276,"name":"Jerome I. Rotter","orcid":"0000-0001-7191-1723","position":13,"is_corresponding":false},{"id":11363,"name":"Charles Kooperberg","orcid":"0000-0002-7986-8560","position":14,"is_corresponding":false},{"id":1133,"name":"James G. Wilson","orcid":"0009-0002-0283-2970","position":15,"is_corresponding":false},{"id":543762,"name":"Jeffery Haessler","orcid":null,"position":16,"is_corresponding":false},{"id":639851,"name":"Paul Auer","orcid":null,"position":17,"is_corresponding":false},{"id":268751,"name":"Robert E. Gerszten","orcid":"0000-0002-6767-7687","position":18,"is_corresponding":false},{"id":11274,"name":"Stephen S. Rich","orcid":"0000-0003-3872-7793","position":19,"is_corresponding":false},{"id":57363,"name":"Teresa E. Seeman","orcid":"0000-0001-8583-4239","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T02:10:47.170978Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}