{"doi":"10.17615/rwet-bf31","title":"Cyclooxygenase-2 Polymorphisms, Aspirin Treatment, and Risk for Colorectal Adenoma Recurrence--Data from a Randomized Clinical Trial","abstract":"Cyclooxygenase-2 (COX-2) catalyzes the rate-limiting step in the production of prostaglandins, potent mediators of inflammation. Chronic inflammation plays an important role in the development and progression of colorectal cancer. Aspirin inhibits COX-2 activity and lowers the risk of colorectal adenomas and cancer. We investigated whether common genetic variation in COX-2 influenced risk of colorectal adenoma recurrence among 979 participants in the Aspirin/Folate Polyp Prevention Study who were randomly assigned to placebo or aspirin and followed for 3 years for the occurrence of new adenomas. Of these participants, 44.2% developed at least one new adenoma during follow-up. Adjusted relative risks (RRs) and 95% confidence intervals (CIs) were calculated to test the association between genetic variation at six COX-2 single nucleotide polymorphisms (SNPs) and adenoma occurrence and interaction with aspirin treatment. Two SNPs were significantly associated with increased adenoma recurrence: for rs5277 homozygous carriers of the minor C allele had a 51% increased risk compared to GG homozygotes (RR=1.51, 95% CI=1.01–2.25), and for rs4648310 heterozygous carriers of the minor G allele had a 37% increased risk compared to AA homozygotes (RR=1.37, 95% CI=1.05–1.79). (There were no minor allele homozygotes.) In stratified analyses, there was suggestive evidence that rs4648319 modified the effect of aspirin. These results support the hypothesis that that COX-2 plays a role in the etiology of colon cancer and may be a target for aspirin chemoprevention and warrant further investigation in other colorectal adenoma and cancer populations.","journal":"UNC Libraries","year":2020,"id":135785,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9542,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":280896,"name":"Robert S. Sandler","orcid":"0000-0002-1323-6245","position":1,"is_corresponding":false},{"id":593320,"name":"Fred Saibil","orcid":"0000-0002-6767-4021","position":2,"is_corresponding":false},{"id":350855,"name":"Robert S. Bresalier","orcid":"0000-0002-9740-281X","position":3,"is_corresponding":false},{"id":342727,"name":"Dennis J. Ahnen","orcid":"0000-0003-1783-1129","position":4,"is_corresponding":false},{"id":19642,"name":"Jiang Gui","orcid":"0000-0001-5377-8914","position":5,"is_corresponding":false},{"id":593321,"name":"Imran Ali","orcid":"0000-0001-6511-8374","position":6,"is_corresponding":false},{"id":593979,"name":"Shirley Tsang","orcid":null,"position":7,"is_corresponding":false},{"id":593980,"name":"Maria V. Grau","orcid":null,"position":8,"is_corresponding":false},{"id":548726,"name":"Carol A. Burke","orcid":"0000-0002-7225-0696","position":9,"is_corresponding":false},{"id":593981,"name":"Leah B. Sansbury","orcid":null,"position":10,"is_corresponding":false},{"id":275329,"name":"John A. Baron","orcid":"0000-0003-3461-1056","position":11,"is_corresponding":false},{"id":549720,"name":"Gail McKeown‐Eyssen","orcid":null,"position":12,"is_corresponding":false},{"id":593982,"name":"David J. Munroe","orcid":null,"position":13,"is_corresponding":false},{"id":275330,"name":"Elizabeth L. Barry","orcid":"0000-0001-9637-3036","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:16:35.237665Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}