{"doi":"10.17615/rvet-xf67","title":"Specific Functions for ERK/MAPK Signaling during PNS Development","abstract":"We have established functions of the stimulus dependent MAPKs, ERK1/2 and ERK5 in DRG, motor neuron, and Schwann cell development. Surprisingly, many aspects of early DRG and motor neuron development were found to be ERK1/2 independent and Erk5 deletion had no obvious effect on embryonic PNS. In contrast, Erk1/2 deletion in developing neural crest resulted in peripheral nerves that were devoid of Schwann cell progenitors, and deletion of Erk1/2 in Schwann cell precursors caused disrupted differentiation and marked hypomyelination of axons. The Schwann cell phenotypes are similar to those reported in neuregulin-1 and ErbB mutant mice and neuregulin effects could not be elicited in glial precursors lacking Erk1/2. ERK/MAPK regulation of myelination was specific to Schwann cells, as deletion in oligodendrocyte precursors did not impair myelin formation, but reduced precursor proliferation. Our data suggest a tight linkage between developmental functions of ERK/MAPK signaling and biological actions of specific RTK-activating factors.","journal":"UNC Libraries","year":2020,"id":116279,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9558,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":544825,"name":"S.E. Shoemaker","orcid":null,"position":1,"is_corresponding":false},{"id":393820,"name":"William D. Snider","orcid":null,"position":2,"is_corresponding":false},{"id":21398,"name":"Daniel H. Geschwind","orcid":"0000-0003-2896-3450","position":3,"is_corresponding":false},{"id":544826,"name":"Steven Hollenback","orcid":null,"position":4,"is_corresponding":false},{"id":247434,"name":"Gary E. Landreth","orcid":"0000-0002-8808-424X","position":5,"is_corresponding":false},{"id":253951,"name":"Xiaoyan Li","orcid":"0000-0001-7166-0135","position":6,"is_corresponding":false},{"id":226823,"name":"Giovanni Coppola","orcid":"0000-0003-2105-1061","position":7,"is_corresponding":false},{"id":543989,"name":"Jian Zhong","orcid":"0000-0003-1026-8695","position":8,"is_corresponding":false},{"id":544827,"name":"Daniel Bonder","orcid":null,"position":9,"is_corresponding":false},{"id":392151,"name":"Yaohong Wu","orcid":"0000-0002-7393-2779","position":10,"is_corresponding":false},{"id":323232,"name":"Zhou Jiang","orcid":"0000-0003-4247-2949","position":11,"is_corresponding":false},{"id":395703,"name":"Jason M. Newbern","orcid":"0000-0003-2865-0112","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:13:44.286758Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}