{"doi":"10.17615/rns4-sm46","title":"VSL#3 probiotic modifies mucosal microbial composition but does not reduce colitis-associated colorectal cancer","abstract":"Although probiotics have shown success in preventing the development of experimental colitis-associated colorectal cancer (CRC), beneficial effects of interventional treatment are relatively unknown. Here we show that interventional treatment with VSL#3 probiotic alters the luminal and mucosally-adherent microbiota, but does not protect against inflammation or tumorigenesis in the azoxymethane (AOM)/Il10−/− mouse model of colitis-associated CRC. VSL#3 (109 CFU/animal/day) significantly enhanced tumor penetrance, multiplicity, histologic dysplasia scores, and adenocarcinoma invasion relative to VSL#3-untreated mice. Illumina 16S sequencing demonstrated that VSL#3 significantly decreased (16-fold) the abundance of a bacterial taxon assigned to genus Clostridium in the mucosally-adherent microbiota. Mediation analysis by linear models suggested that this taxon was a contributing factor to increased tumorigenesis in VSL#3-fed mice. We conclude that VSL#3 interventional therapy can alter microbial community composition and enhance tumorigenesis in the AOM/Il10−/− model.","journal":"UNC Libraries","year":2020,"id":142612,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.961,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":426988,"name":"Sarah Tomkovich","orcid":"0000-0003-1638-5307","position":1,"is_corresponding":false},{"id":237266,"name":"Christian Jobin","orcid":"0000-0002-3733-1001","position":2,"is_corresponding":false},{"id":270825,"name":"Janelle C. Arthur","orcid":"0000-0002-4796-0207","position":3,"is_corresponding":false},{"id":307737,"name":"Marcus Mühlbauer","orcid":"0000-0003-2453-8262","position":4,"is_corresponding":false},{"id":594939,"name":"Wei Sha","orcid":"0000-0002-5453-859X","position":5,"is_corresponding":false},{"id":29081,"name":"Anthony A. Fodor","orcid":"0000-0002-9305-4264","position":6,"is_corresponding":false},{"id":599644,"name":"Joshua M. Uronis","orcid":"0000-0002-2778-1471","position":7,"is_corresponding":false},{"id":245451,"name":"Raad Z. Gharaibeh","orcid":"0000-0001-5484-8902","position":8,"is_corresponding":false},{"id":593972,"name":"Ernesto Peréz-Chanona","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:17:31.424593Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}