{"doi":"10.17615/r9sk-jf71","title":"Multivariable Modeling of Phenotypic Risk Factors for First-Onset TMD: The OPPERA Prospective Cohort Study","abstract":"Incidence of temporomandibular disorders (TMD) was predicted with multivariable models that used putative risk factors collected from initially TMD-free individuals in the Orofacial Pain: Prospective Evaluation and Risk Assessment (OPPERA) study. The 202 baseline risk factors included sociodemographic and clinical characteristics, measures of general health status, experimental pain sensitivity, autonomic function, and psychological distress. Study participants (n=2,737) were then followed prospectively for a median of 2.8 years to ascertain cases of first-onset TMD. Lasso regression and random forest models were used to predict incidence of first-onset TMD using all of the aforementioned measures. Variable importance scores identified the most important risk factors, and their relationship with TMD incidence was illustrated graphically using partial dependence plots. Two of the most important risk factors for elevated TMD incidence were greater numbers of comorbid pain conditions and greater extent of non-specific orofacial symptoms. Other important baseline risk factors were pre-existing bodily pain, heightened somatic awareness, and greater extent of pain in response to examiners’ palpation of the head, neck and body. Several demographic variables persisted as risk factors even after adjusting for other OPPERA variables, suggesting that environmental variables not measured in OPPERA may also contribute to first-onset TMD.","journal":"UNC Libraries","year":2020,"id":143387,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8493,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":79748,"name":"Eric Bair","orcid":"0000-0001-8733-7869","position":1,"is_corresponding":false},{"id":276565,"name":"Ronald Dubner","orcid":null,"position":2,"is_corresponding":false},{"id":301593,"name":"Richard Ohrbach","orcid":"0000-0002-9266-9734","position":3,"is_corresponding":false},{"id":393555,"name":"Luda Diatchenko","orcid":"0000-0002-1350-6727","position":4,"is_corresponding":false},{"id":541052,"name":"Charles Knott","orcid":"0000-0002-3340-1850","position":5,"is_corresponding":false},{"id":561813,"name":"Erika S. Helgeson","orcid":"0000-0001-5170-7100","position":6,"is_corresponding":false},{"id":301597,"name":"Gary D. Slade","orcid":"0000-0002-4065-6341","position":7,"is_corresponding":false},{"id":301594,"name":"Joel D. Greenspan","orcid":"0000-0003-4062-9797","position":8,"is_corresponding":false},{"id":130820,"name":"William Maixner","orcid":null,"position":9,"is_corresponding":false},{"id":301592,"name":"Roger B. Fillingim","orcid":"0000-0002-7699-8183","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:17:38.432803Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}