{"doi":"10.17615/r092-rm77","title":"Altered Proliferative Response by T Lymphocytes of Ly-6A (Sca-1) Null Mice","abstract":"Ly-6A is a murine antigen which is implicated in lymphocyte activation and may be involved in activation of hematopoietic stem cells. Antibody cross-linking studies and antisense experiments have suggested that Ly-6A is a lymphocyte coactivation molecule. To better understand the function of Ly-6A, we used gene targeting to produce Ly-6A null mice which are healthy and have normal numbers and percentages of hematopoietic lineages. However, T lymphocytes from Ly-6A–deficient animals proliferate at a significantly higher rate in response to antigens and mitogens than wild-type littermates. In addition, Ly-6A mutant splenocytes generate more cytotoxic T lymphocytes compared to wild-type splenocytes when cocultured with alloantigen. This enhanced proliferation is not due to alterations in kinetics of response, sensitivity to stimulant concentration, or cytokine production by the T cell population, and is manifest in both in vivo and in vitro T cell responses. Moreover, T cells from Ly-6A–deficient animals exhibit a prolonged proliferative response to antigen stimulation, thereby suggesting that Ly-6A acts to downmodulate lymphocyte responses.","journal":"UNC Libraries","year":2020,"id":136473,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.949,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":595577,"name":"Patrick M. Flood","orcid":null,"position":1,"is_corresponding":false},{"id":595578,"name":"Anne M. Latour","orcid":null,"position":2,"is_corresponding":false},{"id":595579,"name":"Salma Haque","orcid":null,"position":3,"is_corresponding":false},{"id":346343,"name":"H. Ralph Snodgrass","orcid":null,"position":4,"is_corresponding":false},{"id":443717,"name":"Beverly H. Koller","orcid":"0000-0002-1433-359X","position":5,"is_corresponding":false},{"id":594879,"name":"William L. Stanford","orcid":"0000-0002-5813-8016","position":6,"is_corresponding":false},{"id":594880,"name":"Robert Alexander","orcid":"0000-0003-4242-8550","position":7,"is_corresponding":false},{"id":594878,"name":"Xuemei Liu","orcid":"0009-0004-2729-339X","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:16:48.793683Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}