{"doi":"10.17615/qs6b-ev07","title":"Human genome-wide repair map of DNA damage caused by the cigarette smoke carcinogen benzo[a]pyrene","abstract":"Benzo[a]pyrene (BaP) is a widespread potent carcinogen found in food, coal tar, cigarette smoke, and industrial smoke. Cigarette smoking is the leading cause of lung cancer, and the mutagenesis in smoking-associated lung cancer is determined by multiple factors, including nucleotide excision repair. We have developed a general method for genome-wide mapping of nucleotide excision repair at single-nucleotide resolution and applied it to generate repair maps of UV- and BaP-induced DNA damage in human. Results show a novel sequence specificity of BaP diol epoxide-deoxyguanosine repair. This general method can be used to study repair of all types of DNA damages that undergo nucleotide excision repair.","journal":"UNC Libraries","year":2020,"id":117876,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9395,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":549427,"name":"Ogun Adebalia","orcid":null,"position":1,"is_corresponding":false},{"id":227853,"name":"Wentao Li","orcid":"0000-0003-2313-6384","position":2,"is_corresponding":false},{"id":355789,"name":"Yanyan Yang","orcid":"0000-0001-9943-4279","position":3,"is_corresponding":false},{"id":237019,"name":"Aziz Sancar","orcid":"0000-0001-6469-4900","position":4,"is_corresponding":false},{"id":418485,"name":"Yi‐Ying Chiou","orcid":"0000-0002-8742-8848","position":5,"is_corresponding":false},{"id":528965,"name":"Jinchuan Hu","orcid":"0000-0001-7096-0195","position":6,"is_corresponding":false},{"id":251360,"name":"Sheera Adar","orcid":"0000-0002-9767-3740","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:13:54.951170Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}