{"doi":"10.17615/qp2v-ky62","title":"Dietary intake of fish, polyunsaturated fatty acids, and survival after breast cancer: A population-based follow-up study on Long Island, New York","abstract":"BACKGROUND In laboratory experiments, ω-3 polyunsaturated fatty acids (PUFAs) have been found to reduce inflammatory eicosanoids resulting from ω-6 PUFA metabolism via competitive inhibition, and the ω-3-induced cytotoxic environment increases apoptosis and reduces cell growth in breast cancer cells. To the authors' knowledge, epidemiologic investigations regarding whether dietary ω-3 PUFA intake benefits survival after breast cancer are limited and inconsistent. METHODS The authors used resources from a population-based follow-up study conducted on Long Island, New York, among 1463 women newly diagnosed with first primary breast cancer who were interviewed an average of approximately 3 months after diagnosis to assess risk and prognostic factors, including dietary intake (using a food frequency questionnaire). Vital status was determined through 2011, yielding a median follow-up of 14.7 years and 485 deaths. Adjusted hazard ratios (HRs) and 95% confidence intervals (95% CIs) were estimated using Cox proportional hazards regression. RESULTS All-cause mortality was reduced among women with breast cancer reporting the highest quartile of intake (compared with never) for tuna (HR, 0.71; 95% CI, 0.55-0.92), other baked/broiled fish (HR, 0.75; 95% CI, 0.58-0.97), and the dietary long-chain ω-3 PUFAs docosahexaenoic acid (HR, 0.71; 95% CI, 0.55-0.92) and eicosapentaenoic acid (HR, 0.75; 95% CI, 0.58-0.97). CONCLUSIONS All-cause mortality was reduced by 16% to 34% among women with breast cancer who reported a high intake of fish and long-chain ω-3 PUFAs. Long-chain ω-3 PUFA intake from fish and other dietary sources may provide a potential strategy to improve survival after breast cancer. Cancer 2015;121:2244-2252.","journal":"UNC Libraries","year":2024,"id":499179,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9568,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":980426,"name":"S.L. Teitelbaum","orcid":null,"position":1,"is_corresponding":false},{"id":261928,"name":"Andrew F. Olshan","orcid":"0000-0001-9115-5128","position":2,"is_corresponding":false},{"id":980427,"name":"P.T. Bradshaw","orcid":null,"position":3,"is_corresponding":false},{"id":369709,"name":"Nikhil K. Khankari","orcid":"0000-0002-8802-4431","position":4,"is_corresponding":false},{"id":347018,"name":"Susan E. Steck","orcid":"0000-0002-3201-9537","position":5,"is_corresponding":false},{"id":980428,"name":"R.M. Santella","orcid":null,"position":6,"is_corresponding":false},{"id":980425,"name":"A.I. Neugut","orcid":null,"position":7,"is_corresponding":false},{"id":291708,"name":"Jiyoung Ahn","orcid":"0000-0002-2900-2304","position":8,"is_corresponding":false},{"id":763670,"name":"Jing Shen","orcid":"0000-0003-0867-597X","position":9,"is_corresponding":false},{"id":302468,"name":"Yu Chen","orcid":"0000-0002-1519-4894","position":10,"is_corresponding":false},{"id":251556,"name":"Mary Beth Terry","orcid":"0000-0002-4106-5033","position":11,"is_corresponding":false},{"id":980429,"name":"M.D. Gammon","orcid":null,"position":12,"is_corresponding":false},{"id":226942,"name":"Habibul Ahsan","orcid":"0000-0001-9808-377X","position":13,"is_corresponding":false},{"id":1346250,"name":"Kang He","orcid":"0000-0001-9621-9258","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T02:09:45.971055Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}