{"doi":"10.17615/qmbw-yn72","title":"Molecular Profiling Reveals Prognostically Significant Subtypes of Canine Lymphoma","abstract":"We performed genomewide gene expression analysis of 35 samples representing 6 common histologic subtypes of canine lymphoma and bioinformatics analyses to define their molecular characteristics. Three major groups were defined on the basis of gene expression profiles: (1) low-grade T-cell lymphoma, composed entirely by T-zone lymphoma; (2) high-grade T-cell lymphoma, consisting of lymphoblastic T-cell lymphoma and peripheral T-cell lymphoma not otherwise specified; and (3) B-cell lymphoma, consisting of marginal B-cell lymphoma, diffuse large B-cell lymphoma, and Burkitt lymphoma. Interspecies comparative analyses of gene expression profiles also showed that marginal B-cell lymphoma and diffuse large B-cell lymphoma in dogs and humans might represent a continuum of disease with similar drivers. The classification of these diverse tumors into 3 subgroups was prognostically significant, as the groups were directly correlated with event-free survival. Finally, we developed a benchtop diagnostic test based on expression of 4 genes that can robustly classify canine lymphomas into one of these 3 subgroups, enabling a direct clinical application for our results.","journal":"UNC Libraries","year":2020,"id":114571,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9484,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":539025,"name":"M. C. Scott","orcid":null,"position":1,"is_corresponding":false},{"id":539026,"name":"A. Borgatti","orcid":null,"position":2,"is_corresponding":false},{"id":538058,"name":"Brian D. Husbands","orcid":"0000-0003-0966-4439","position":3,"is_corresponding":false},{"id":538059,"name":"Timothy D. O’Brien","orcid":"0000-0001-9742-0930","position":4,"is_corresponding":false},{"id":539027,"name":"M. Breen","orcid":null,"position":5,"is_corresponding":false},{"id":539028,"name":"A. L. Sarver","orcid":null,"position":6,"is_corresponding":false},{"id":539029,"name":"K. Lindblad-Toh","orcid":null,"position":7,"is_corresponding":false},{"id":538060,"name":"Daisuke Ito","orcid":"0009-0006-2378-5201","position":8,"is_corresponding":false},{"id":539030,"name":"M. S. Henson","orcid":null,"position":9,"is_corresponding":false},{"id":539031,"name":"W. C. Kisseberth","orcid":null,"position":10,"is_corresponding":false},{"id":539032,"name":"A. M. Frantz","orcid":null,"position":11,"is_corresponding":false},{"id":539033,"name":"A. Karimpour-Fard","orcid":null,"position":12,"is_corresponding":false},{"id":393152,"name":"Jaime F. Modiano","orcid":"0000-0001-6398-7648","position":13,"is_corresponding":false},{"id":539034,"name":"K. E. Burgess","orcid":null,"position":14,"is_corresponding":false},{"id":539035,"name":"V. E. Valli","orcid":null,"position":15,"is_corresponding":false},{"id":539036,"name":"L. E. Hunter","orcid":null,"position":16,"is_corresponding":false},{"id":539024,"name":"T. L. Phang","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:13:29.674622Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}