{"doi":"10.17615/qf66-d592","title":"Engineering threshold-based selection systems","abstract":"Using model organisms to identify novel therapeutic targets is frequently constrained by pre-existing genetic toolkits. To expedite positive selection for identification of novel downstream effectors, we engineered conditional expression of activated CED-10/Rac to disrupt Caenorhabditis elegans embryonic morphogenesis, titrated to 100% lethality. The strategy of engineering thresholds for positive selection using experimental animals was validated with pharmacological and genetic suppression and is generalizable to diverse molecular processes and experimental systems.","journal":"UNC Libraries","year":2022,"id":310181,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9571,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1005995,"name":"K.H. Pedone","orcid":null,"position":1,"is_corresponding":false},{"id":752948,"name":"A.D. Cox","orcid":null,"position":2,"is_corresponding":false},{"id":135925,"name":"S. Ahmed","orcid":null,"position":3,"is_corresponding":false},{"id":1005996,"name":"L.E. Leopold","orcid":null,"position":4,"is_corresponding":false},{"id":1005997,"name":"D.J. Reiner","orcid":null,"position":5,"is_corresponding":false},{"id":1005998,"name":"V. González-Pérez","orcid":null,"position":6,"is_corresponding":false},{"id":541321,"name":"C.J. Der","orcid":null,"position":7,"is_corresponding":false},{"id":1005994,"name":"N.R. Rasmussen","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T00:33:19.712967Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}