{"doi":"10.17615/p7za-vh37","title":"Loss of UBE3A from TH-expressing neurons suppresses GABA co-release and enhances VTA-NAc optical self-stimulation","abstract":"Motivated reward-seeking behaviours are governed by dopaminergic ventral tegmental area projections to the nucleus accumbens. In addition to dopamine, these mesoaccumbal terminals co-release other neurotransmitters including glutamate and GABA, whose roles in regulating motivated behaviours are currently being investigated. Here we demonstrate that loss of the E3-ubiquitin ligase, UBE3A, from tyrosine hydroxylase-expressing neurons impairs mesoaccumbal, non-canonical GABA co-release and enhances reward-seeking behaviour measured by optical self-stimulation.","journal":"UNC Libraries","year":2020,"id":138271,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9448,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":491118,"name":"Megumi Aita","orcid":null,"position":1,"is_corresponding":false},{"id":275074,"name":"Benjamin D. Philpot","orcid":"0000-0003-2746-9143","position":2,"is_corresponding":false},{"id":380076,"name":"Janet Berrios","orcid":null,"position":3,"is_corresponding":false},{"id":548562,"name":"Matthew C. Judson","orcid":"0000-0001-8659-1654","position":4,"is_corresponding":false},{"id":317249,"name":"Zoé A. McElligott","orcid":"0000-0002-4717-5698","position":5,"is_corresponding":false},{"id":249206,"name":"Garret D. Stuber","orcid":"0000-0003-1730-4855","position":6,"is_corresponding":false},{"id":481351,"name":"Marie Rougié","orcid":"0000-0001-5797-7515","position":7,"is_corresponding":false},{"id":528905,"name":"Alice M. Stamatakis","orcid":"0000-0002-3458-2139","position":8,"is_corresponding":false},{"id":549279,"name":"Pranish A. Kantak","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:17:02.849477Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}