{"doi":"10.17615/p553-k525","title":"Vaginal Delivery of Paclitaxel via Nanoparticles with Non-Mucoadhesive Surfaces Suppresses Cervical Tumor Growth","abstract":"Local delivery of chemotherapeutics in the cervicovaginal tract using nanoparticles may reduce adverse side effects associated with systemic chemotherapy, while improving outcomes for early stage cervical cancer. We hypothesize drug-loaded nanoparticles must rapidly penetrate cervicovaginal mucus (CVM) lining the female reproductive tract to effectively deliver their payload to underlying diseased tissues in a uniform and sustained manner. We develop paclitaxel-loaded nanoparticles, composed entirely of polymers used in FDA-approved products, which rapidly penetrate human CVM and provide sustained drug release with minimal burst effect. We further employ a mouse model with aggressive cervical tumors established in the cervicovaginal tract to compare paclitaxel-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (conventional particles , or CP) and similar particles coated with Pluronic® F127 (mucus-penetrating particles , or MPP). CP are mucoadhesive and, thus, aggregated in mucus, while MPP achieve more uniform distribution and close proximity to cervical tumors. Paclitaxel-MPP suppress tumor growth more effectively and prolong median survival of mice compared to free paclitaxel or paclitaxel-CP. Histopathological studies demonstrate minimal toxicity to the cervicovaginal epithelia, suggesting paclitaxel-MPP may be safe for intravaginal use. These results demonstrate for the first time the in vivo advantages of polymer-based MPP for treatment of tumors localized to a mucosal surface.","journal":"UNC Libraries","year":2020,"id":117581,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9451,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":548221,"name":"T. C. Wu","orcid":null,"position":1,"is_corresponding":false},{"id":269610,"name":"Justin Hanes","orcid":null,"position":2,"is_corresponding":false},{"id":257982,"name":"Brian W. Simons","orcid":"0000-0003-0644-211X","position":3,"is_corresponding":false},{"id":548222,"name":"Chih Yin Juang","orcid":null,"position":4,"is_corresponding":false},{"id":42022,"name":"Chien‐Fu Hung","orcid":"0000-0001-9170-7797","position":5,"is_corresponding":false},{"id":547210,"name":"Joseph Wood","orcid":"0000-0003-2040-5497","position":6,"is_corresponding":false},{"id":14845,"name":"Tao Yu","orcid":"0000-0001-7896-4625","position":7,"is_corresponding":false},{"id":547211,"name":"Qi Zeng","orcid":"0000-0002-3696-1538","position":8,"is_corresponding":false},{"id":285635,"name":"Samuel K. Lai","orcid":"0000-0003-4721-528X","position":9,"is_corresponding":false},{"id":268581,"name":"Laura M. Ensign","orcid":"0000-0002-6949-7911","position":10,"is_corresponding":false},{"id":548223,"name":"Bolong Miao","orcid":null,"position":11,"is_corresponding":false},{"id":411848,"name":"Michael T. McMahon","orcid":"0000-0002-8917-7640","position":12,"is_corresponding":false},{"id":547212,"name":"Olcay Mert","orcid":"0000-0002-5769-8994","position":13,"is_corresponding":false},{"id":429880,"name":"Guanshu Liu","orcid":"0000-0002-8188-4332","position":14,"is_corresponding":false},{"id":440280,"name":"Benjamin C. Tang","orcid":"0000-0002-3807-0480","position":15,"is_corresponding":false},{"id":547213,"name":"Yingying Wang","orcid":"0000-0003-4363-8779","position":16,"is_corresponding":false},{"id":271392,"name":"Kannie W. Y. Chan","orcid":"0000-0002-7315-1550","position":17,"is_corresponding":false},{"id":547214,"name":"Ming Yang","orcid":"0000-0002-1617-9960","position":18,"is_corresponding":false},{"id":355315,"name":"Jie Fu","orcid":"0000-0001-5864-3488","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:13:51.309289Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}