{"doi":"10.17615/p4zk-kt53","title":"Extended Human Papillomavirus Genotyping to Predict Progression to High-Grade Cervical Precancer: A Prospective Cohort Study in the Southeastern United States","abstract":"Background: High-risk human papillomavirus (hrHPV) testing (HPV16; else HPV18/45; else HPV31/33/35/52/58; else HPV39/ is utilized in primary cervical cancer screening, generally along with 51/56/59/68). cytology, to triage abnormalities to colposcopy. Most screening-Results: At enrollment, median participant age was 30.1 years; based hrHPV testing involves pooled detection of any hrHPV or of most (63%) were hrHPV-positive. Over follow-up, 24 participants HPV16/18. Cervical neoplasia progression risks based on extended progressed to CIN2þ (7.0%). CIN2þ IR among hrHPV-positive hrHPV genotyping—particularly non-16/18 hrHPV types—are not participants was 3.4/1,000 person-months. CIN2þ IRs were highest well characterized. HPV genotype-specific incidence of high-grade for HPV16 (8.3), HPV33 (7.8), and HPV58 (4.9). Five-year CIN2þ cervical intraepithelial neoplasia or more severe (CIN2þ) following risk was higher for HPV16 (0.34) compared with HPV18/45 (0.12), an abnormal screening result was examined. HPV31/33/35/52/58 (0.12), and HPV39/51/56/59/68 (0.16) (P ¼ 0.05). Methods: We assessed a US-based prospective, multiracial, Conclusions: Non-16/18 hrHPV types are associated with difclinical cohort of 343 colposcopy patients with normal histology ferential CIN2þ progression rates. HPV16, 33, and 58 exhibited the (n ¼ 226) or CIN1 (n ¼ 117). Baseline cervical samples underwent highest rates over 5 years. HPV risk groups warrant further invesHPV DNA genotyping, and participants were followed up to 5 years. tigation in diverse US populations. Genotype-specific CIN2þ incidence rates (IR) were estimated with Impact: These novel data assessing extended HPV genotyping in accelerated failure time models. Five-year CIN2þ risks were estia diverse clinical cohort can inform future directions to improve mated nonparametrically for hierarchical hrHPV risk groups screening practices in the general population.","journal":"UNC Libraries","year":2024,"id":499083,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.946,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":270428,"name":"Rachel L. Maguire","orcid":"0000-0001-6421-2545","position":1,"is_corresponding":false},{"id":526071,"name":"K.E. North","orcid":null,"position":2,"is_corresponding":false},{"id":1345935,"name":"Jürgen Schmitt","orcid":"0000-0003-3472-4464","position":3,"is_corresponding":false},{"id":453988,"name":"J.S. Smith","orcid":null,"position":4,"is_corresponding":false},{"id":270429,"name":"Susan K. Murphy","orcid":"0000-0001-8298-7272","position":5,"is_corresponding":false},{"id":594584,"name":"Fidel A. Valea","orcid":"0000-0002-4844-2399","position":6,"is_corresponding":false},{"id":258281,"name":"Cathrine Hoyo","orcid":"0000-0002-2466-8617","position":7,"is_corresponding":false},{"id":474119,"name":"M.G. Hudgens","orcid":null,"position":8,"is_corresponding":false},{"id":33513,"name":"Rex C. Bentley","orcid":"0000-0002-4947-9150","position":9,"is_corresponding":false},{"id":453040,"name":"Wendy R. Brewster","orcid":"0000-0001-6150-3160","position":10,"is_corresponding":false},{"id":944463,"name":"Alexandra Bukowski","orcid":"0000-0001-7634-7340","position":11,"is_corresponding":false},{"id":325360,"name":"Adriana C. Vidal","orcid":"0000-0002-3240-6668","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T02:09:45.971055Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}