{"doi":"10.17615/nwds-m369","title":"Ethnoracial Disparities in SARS-CoV-2 Seroprevalence in a Large Cohort of Individuals in Central North Carolina from April to December 2020","abstract":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused millions of deaths around the world within the past 2 years. Transmission within the United States has been heterogeneously distributed by geography and social factors with little data from North Carolina. Here, we describe results from a weekly cross-sectional study of 12,471 unique hospital remnant samples from 19 April to 26 December 2020 collected by four clinical sites within the University of North Carolina Health system, with a majority of samples from urban, outpatient populations in central North Carolina. We employed a Bayesian inference model to calculate SARS-CoV-2 spike protein immunoglobulin prevalence estimates and conditional odds ratios for seropositivity. Furthermore, we analyzed a subset of these seropositive samples for neutralizing antibodies. We observed an increase in seroprevalence from 2.9 (95% confidence interval [CI], 1.8 to 4.5) to 12.8 (95% CI, 10.6 to 15.2) over the course of the study. Latinx individuals had the highest odds ratio of SARS-CoV-2 exposure at 6.56 (95% CI, 4.66 to 9.44). Our findings aid in quantifying the degree of asymmetric SARS-CoV-2 exposure by ethnoracial grouping. We also find that 49% of a subset of seropositive individuals had detectable neutralizing antibodies, which was skewed toward those with recent respiratory infection symptoms.","journal":"UNC Libraries","year":2023,"id":415820,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9472,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":954689,"name":"Cinthia Newberry-Dillon","orcid":null,"position":1,"is_corresponding":false},{"id":333592,"name":"Daniel B. 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Adimora","orcid":"0000-0001-5035-1552","position":12,"is_corresponding":false},{"id":2100,"name":"Kim D. Pruitt","orcid":"0000-0001-7950-1374","position":13,"is_corresponding":false},{"id":954688,"name":"Carolyn Amditis","orcid":null,"position":14,"is_corresponding":false},{"id":954686,"name":"Christine Wiethorn","orcid":null,"position":15,"is_corresponding":false},{"id":429330,"name":"Matthew J. Delacruz","orcid":null,"position":16,"is_corresponding":false},{"id":492235,"name":"John L. Schmitz","orcid":"0000-0002-1425-236X","position":17,"is_corresponding":false},{"id":515702,"name":"J.J. Juliano","orcid":null,"position":18,"is_corresponding":false},{"id":667051,"name":"Quique Guerra","orcid":null,"position":19,"is_corresponding":false},{"id":665978,"name":"D. Ryan Bhowmik","orcid":"0000-0001-6979-5460","position":20,"is_corresponding":false},{"id":834864,"name":"Y.J. Hou","orcid":null,"position":21,"is_corresponding":false},{"id":1198291,"name":"L. Premkumar","orcid":null,"position":22,"is_corresponding":false},{"id":109254,"name":"Allison E. Aiello","orcid":"0000-0001-7029-2537","position":23,"is_corresponding":false},{"id":1179908,"name":"A.J. Markmann","orcid":null,"position":24,"is_corresponding":false},{"id":337676,"name":"Samuel Goldstein","orcid":"0000-0003-1752-0996","position":25,"is_corresponding":false},{"id":31614,"name":"K. Brandt","orcid":null,"position":26,"is_corresponding":false},{"id":954685,"name":"Margaret Gearhart","orcid":null,"position":27,"is_corresponding":false},{"id":22734,"name":"C. 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