{"doi":"10.17615/nprr-q654","title":"Expression of microRNAs is dynamically regulated during cardiomyocyte hypertrophy","abstract":"MicroRNAs (miRNAs) are a recently discovered class of ∼22-nucleotide regulatory RNAs that post-transcriptionally regulate gene expression. We have recently demonstrated that muscle-specific miRNAs miR-1 and -133 play an important role in modulating muscle proliferation and differentiation. Here, we investigate the involvement of miRNAs in cardiac hypertrophy. We analyzed the global expression of miRNAs in agonist-induced hypertrophic cardiomyocytes as well as in pressure overload-induced hypertrophic hearts and found the miRNA expression profile altered in those hypertrophic conditions. We further show that inhibition of endogenous miR-21 or -18b augments hypertrophic growth. Conversely, introduction of functional miR-21 or -18b into cardiomyocytes represses myocyte hypertrophy. Together, our studies point to miRNAs as critical regulators of cardiac hypertrophy.","journal":"UNC Libraries","year":2020,"id":135569,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9551,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":237173,"name":"Mauricio Rojas","orcid":"0000-0001-7340-4784","position":1,"is_corresponding":false},{"id":239170,"name":"J. Michael Thomson","orcid":null,"position":2,"is_corresponding":false},{"id":593130,"name":"Martin Newman","orcid":null,"position":3,"is_corresponding":false},{"id":592341,"name":"Thomas E. Callis","orcid":"0000-0001-7670-5443","position":4,"is_corresponding":false},{"id":549294,"name":"Mariko Tatsuguchi","orcid":null,"position":5,"is_corresponding":false},{"id":304625,"name":"Jian‐Fu Chen","orcid":"0000-0002-9474-5673","position":6,"is_corresponding":false},{"id":506682,"name":"Heeyoung Seok","orcid":"0000-0003-2699-9935","position":7,"is_corresponding":false},{"id":238232,"name":"Da‐Zhi Wang","orcid":"0000-0003-1774-6549","position":8,"is_corresponding":false},{"id":239171,"name":"Scott M. Hammond","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:16:31.787520Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}