{"doi":"10.17615/nf72-ba86","title":"Lck regulates Vav activation of members of the Rho family of GTPases.","abstract":"Vav is a member of a family of oncogene proteins that share an approximately 250-amino-acid motif called a Dbl homology domain. Paradoxically, Dbl itself and other proteins containing a Dbl domain catalyze GTP-GDP exchange for Rho family proteins, whereas Vav has been reported to catalyze GTP-GDP exchange for Ras proteins. We present Saccharomyces cerevisiae genetic data, in vitro biochemical data, and animal cell biological data indicating that Vav is a guanine nucleotide exchange factor for Rho-related proteins, but in similar genetic and biochemical experiments we fail to find evidence that Vav is a guanine nucleotide exchange factor for Ras. Further, we present data indicating that the Lck kinase activates the guanine nucleotide exchange factor and transforming activity of Vav.","journal":"UNC Libraries","year":2020,"id":109399,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9532,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":522912,"name":"W Wei","orcid":null,"position":1,"is_corresponding":false},{"id":522913,"name":"R D Mosteller","orcid":null,"position":2,"is_corresponding":false},{"id":522914,"name":"D Broek","orcid":null,"position":3,"is_corresponding":false},{"id":522915,"name":"R Khosravi-Far","orcid":null,"position":4,"is_corresponding":false},{"id":322312,"name":"Linda Van Aelst","orcid":"0000-0002-0870-012X","position":5,"is_corresponding":false},{"id":212852,"name":"J Han","orcid":null,"position":6,"is_corresponding":false},{"id":522916,"name":"J K Westwick","orcid":null,"position":7,"is_corresponding":false},{"id":522917,"name":"C J Der","orcid":null,"position":8,"is_corresponding":false},{"id":179566,"name":"B Das","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:12:50.712357Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}