{"doi":"10.17615/ndmh-4q94","title":"Mst1 Directs Myosin IIa Partitioning of Low and Higher Affinity Integrins during T Cell Migration","abstract":"Chemokines promote T cell migration by transmitting signals that induce T cell polarization and integrin activation and adhesion. Mst1 kinase is a key signal mediator required for both of these processes; however, its molecular mechanism remains unclear. Here, we present a mouse model in which Mst1 function is disrupted by a hypomorphic mutation. Microscopic analysis of Mst1-deficient CD4 T cells revealed a necessary role for Mst1 in controlling the localization and activity of Myosin IIa, a molecular motor that moves along actin filaments. Using affinity specific LFA-1 antibodies, we identified a requirement for Myosin IIa-dependent contraction in the precise spatial distribution of low and higher affinity LFA-1 on the membrane of migrating T cells. Mst1 deficiency or Myosin inhibition resulted in multipolar cells, difficulties in uropod detachment and mis-localization of low affinity LFA-1. Thus, Mst1 regulates Myosin IIa dynamics to organize high and low affinity LFA-1 to the anterior and posterior membrane during T cell migration.","journal":"UNC Libraries","year":2020,"id":142291,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9568,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":608852,"name":"Xinxin Wang","orcid":"0000-0002-0286-3681","position":1,"is_corresponding":false},{"id":608853,"name":"Karsten Sauer","orcid":"0000-0002-8355-9429","position":2,"is_corresponding":false},{"id":381711,"name":"Michael P. Cooke","orcid":"0000-0003-2081-3466","position":3,"is_corresponding":false},{"id":591984,"name":"Tim Wiltshire","orcid":"0000-0001-5960-4034","position":4,"is_corresponding":false},{"id":609306,"name":"Emily R. Jaeger","orcid":null,"position":5,"is_corresponding":false},{"id":383589,"name":"John R. Walker","orcid":"0000-0002-5349-1689","position":6,"is_corresponding":false},{"id":609307,"name":"Nancy L. Mathis","orcid":null,"position":7,"is_corresponding":false},{"id":364412,"name":"Xiaolu Xu","orcid":"0009-0006-5887-2620","position":8,"is_corresponding":false},{"id":609308,"name":"Erica Lagler-Ferrez","orcid":null,"position":9,"is_corresponding":false},{"id":608854,"name":"Serge Batalov","orcid":"0000-0002-0925-0554","position":10,"is_corresponding":false},{"id":292415,"name":"Yina H. Huang","orcid":"0000-0002-0125-9351","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:17:31.424593Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}