{"doi":"10.17615/n33k-1a38","title":"Weight and Body Mass Index Change after Switching to Integrase Inhibitors or Tenofovir Alafenamide among Women Living with HIV","abstract":"Weight and body mass index (BMI) change was assessed among women after switch to integrase inhibitors (INSTIs) and/or tenofovir alafenamide (TAF). From 2006 to 2019, 1,458 women living with HIV enrolled in the Women's Interagency HIV Study and on antiretroviral therapy (ART) with ≥1 study visit before and after switching to INSTIs and/or TAF were included. Weight and BMI were compared pre- and postswitch to INSTI (by class and type) and/or TAF using multivariable linear mixed effects models; all models were also stratified by preswitch presence or absence of obesity (BMI ≥30 vs. <30 kg/m2). Mean age preswitch was 47 ± 6 years, 64% were black, mean CD4 = 475 ± 201 cells/mm3, 56% had HIV RNA <200 copies/mL, 36% switched to TAF but not INSTI, 60% to INSTI but not TAF, and 3.5% to TAF+INSTI. Time from pre- to postswitch was 12.8 ± 11.8 months. The INSTI-only group but not TAF groups had small but significant increases in weight and BMI: mean 79.2-80.6 kg and 30.2-30.7 kg/m2, p's < .001, respectively, with congruent findings by INSTI type (p's ≤ .01). In stratified (preswitch BMI) analyses, only nonobese subgroups experienced increases in weight and BMI across all ART treatment groups (p's < .05). Significant, although small-to-medium, increases in weight and BMI occurred among nonobese women who switched to INSTIs and/or TAF over short follow-up. Given long-term health consequences of obesity particularly as a low-grade inflammatory condition, identifying women at highest risk of ART-associated weight gain is imperative.","journal":"UNC Libraries","year":2023,"id":415821,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9222,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":709044,"name":"Juan A. García Álvarez","orcid":"0000-0003-4233-7958","position":1,"is_corresponding":false},{"id":1197928,"name":"Kaiying Wang","orcid":"0000-0002-0018-0959","position":2,"is_corresponding":false},{"id":591356,"name":"A.A. Adimora","orcid":null,"position":3,"is_corresponding":false},{"id":404728,"name":"Amanda B. Spence","orcid":"0000-0001-9011-8456","position":4,"is_corresponding":false},{"id":150354,"name":"Phyllis C. Tien","orcid":null,"position":5,"is_corresponding":false},{"id":690554,"name":"Cecile D. Lahiri","orcid":"0000-0002-5605-8266","position":6,"is_corresponding":false},{"id":1159604,"name":"A.N. Sheth","orcid":null,"position":7,"is_corresponding":false},{"id":239817,"name":"Yang Xu","orcid":"0000-0003-1468-2703","position":8,"is_corresponding":false},{"id":259653,"name":"Jane A. O’Halloran","orcid":"0000-0001-8265-9471","position":9,"is_corresponding":false},{"id":597010,"name":"M. Fischl","orcid":null,"position":10,"is_corresponding":false},{"id":597009,"name":"D. Konkle-Parker","orcid":null,"position":11,"is_corresponding":false},{"id":303364,"name":"Ighovwerha Ofotokun","orcid":null,"position":12,"is_corresponding":false},{"id":284935,"name":"Deborah Gustafson","orcid":"0000-0001-9556-8560","position":13,"is_corresponding":false},{"id":259565,"name":"Leah H. Rubin","orcid":"0000-0003-2749-6328","position":14,"is_corresponding":false},{"id":1159138,"name":"A. Sharma","orcid":"0009-0001-4508-3984","position":15,"is_corresponding":false},{"id":596999,"name":"J. Milam","orcid":null,"position":16,"is_corresponding":false},{"id":343372,"name":"Kathleen M. Weber","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T01:22:15.958504Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}