{"doi":"10.17615/n00w-pm15","title":"Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis","abstract":"Metastasis remains a leading cause of cancer mortality due to the lack of specific inhibitors against this complex process. To identify compounds selectively targeting the metastatic state, we used the perinuclear compartment (PNC), a complex nuclear structure associated with metastatic behaviors of cancer cells, as a phenotypic marker for a high-content screen of over 140,000 structurally diverse compounds. Metarrestin, obtained through optimization of a screening hit, disassembles PNCs in multiple cancer cell lines, inhibits invasion in vitro, suppresses metastatic development in three mouse models of human cancer, and extends survival of mice in a metastatic pancreatic cancer xenograft model with no organ toxicity or discernable adverse effects. Metarrestin disrupts the nucleolar structure and inhibits RNA polymerase (Pol) I transcription, at least in part by interacting with the translation elongation factor eEF1A2. Thus, metarrestin represents a potential therapeutic approach for the treatment of metastatic cancer.","journal":"UNC Libraries","year":2022,"id":311861,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9547,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1008714,"name":"Z. Knotts","orcid":null,"position":1,"is_corresponding":false},{"id":1008715,"name":"Chunfeng Long Long","orcid":null,"position":2,"is_corresponding":false},{"id":975729,"name":"Yiheng Bian","orcid":"0009-0004-8628-1751","position":3,"is_corresponding":false},{"id":976219,"name":"Y. Teper","orcid":null,"position":4,"is_corresponding":false},{"id":1008716,"name":"M.A. Lewandowska","orcid":null,"position":5,"is_corresponding":false},{"id":1008717,"name":"L.M. Griner","orcid":null,"position":6,"is_corresponding":false},{"id":1008718,"name":"J. Norton","orcid":null,"position":7,"is_corresponding":false},{"id":945840,"name":"J. Aubé","orcid":null,"position":8,"is_corresponding":false},{"id":1006096,"name":"F.J. Schoenen","orcid":null,"position":9,"is_corresponding":false},{"id":1008719,"name":"A. Mazar","orcid":null,"position":10,"is_corresponding":false},{"id":1008720,"name":"A. Shilatifard","orcid":null,"position":11,"is_corresponding":false},{"id":1008338,"name":"Wenbo Sun","orcid":"0000-0002-5301-4938","position":12,"is_corresponding":false},{"id":76504,"name":"J. Kang","orcid":null,"position":13,"is_corresponding":false},{"id":1008721,"name":"J.J. Marugan","orcid":null,"position":14,"is_corresponding":false},{"id":1008339,"name":"Dengfeng Li","orcid":"0000-0001-8616-904X","position":15,"is_corresponding":false},{"id":979667,"name":"N. Southall","orcid":null,"position":16,"is_corresponding":false},{"id":549663,"name":"Sheng-Dong HUANG","orcid":null,"position":17,"is_corresponding":false},{"id":1008722,"name":"S.J. Baserga","orcid":null,"position":18,"is_corresponding":false},{"id":184599,"name":"M. Ferrer","orcid":null,"position":19,"is_corresponding":false},{"id":976224,"name":"A.S. Powers","orcid":null,"position":20,"is_corresponding":false},{"id":10634,"name":"C. Wang","orcid":"0000-0001-7904-5372","position":21,"is_corresponding":false},{"id":1008723,"name":"H.S. Quadri","orcid":null,"position":22,"is_corresponding":false},{"id":969829,"name":"K.J. Frankowski","orcid":null,"position":23,"is_corresponding":false},{"id":534369,"name":"H. Huang","orcid":null,"position":24,"is_corresponding":false},{"id":1008340,"name":"Weiqing Chen","orcid":"0009-0004-9139-2018","position":25,"is_corresponding":false},{"id":1008724,"name":"H.R. Kim","orcid":null,"position":26,"is_corresponding":false},{"id":832595,"name":"Elsbeth Chow","orcid":null,"position":27,"is_corresponding":false},{"id":115707,"name":"W. Zheng","orcid":null,"position":28,"is_corresponding":false},{"id":320657,"name":"Mian Zhou","orcid":"0000-0003-4226-6299","position":29,"is_corresponding":false},{"id":1008725,"name":"Dengchao Hu","orcid":null,"position":30,"is_corresponding":false},{"id":979663,"name":"S. Titus","orcid":null,"position":31,"is_corresponding":false},{"id":1008726,"name":"T. Vilimas","orcid":null,"position":32,"is_corresponding":false},{"id":1008727,"name":"Yi‐Jun Wen","orcid":null,"position":33,"is_corresponding":false},{"id":1008728,"name":"C. Dextras","orcid":null,"position":34,"is_corresponding":false},{"id":1008729,"name":"K. Nagashima","orcid":null,"position":35,"is_corresponding":false},{"id":1008730,"name":"J. Sultan","orcid":null,"position":36,"is_corresponding":false},{"id":569558,"name":"M. Fang","orcid":null,"position":37,"is_corresponding":false},{"id":545151,"name":"S. Kozlov","orcid":null,"position":38,"is_corresponding":false},{"id":1008731,"name":"I. Kandela","orcid":null,"position":39,"is_corresponding":false},{"id":1008732,"name":"E. Goldberg","orcid":null,"position":40,"is_corresponding":false},{"id":1008733,"name":"O. Khanolkar","orcid":null,"position":41,"is_corresponding":false},{"id":1008734,"name":"S. Patnaik","orcid":null,"position":42,"is_corresponding":false},{"id":1008735,"name":"K.I. Farley","orcid":null,"position":43,"is_corresponding":false},{"id":1008736,"name":"C. Feldman","orcid":null,"position":44,"is_corresponding":false},{"id":1008737,"name":"Ziyue Meng","orcid":null,"position":45,"is_corresponding":false},{"id":1008738,"name":"R. Xi","orcid":null,"position":46,"is_corresponding":false},{"id":1008739,"name":"G. Sahagian","orcid":null,"position":47,"is_corresponding":false},{"id":976213,"name":"U. Rudloff","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T00:33:32.327694Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}