{"doi":"10.17615/mpbh-wr43","title":"Zinc cyclic di-AMP nanoparticles target and suppress tumours via endothelial STING activation and tumour-associated macrophage reinvigoration","abstract":"The clinical utility of stimulator of interferon genes (STING) agonists has been limited due to poor tumour-targeting and unwanted toxicity following systemic delivery. Here we describe a robust tumour-targeted STING agonist, ZnCDA, formed by the encapsulation of bacterial-derived cyclic dimeric adenosine monophosphate (CDA) in nanoscale coordination polymers. Intravenously injected ZnCDA prolongs CDA circulation and efficiently targets tumours, mediating robust anti-tumour effects in a diverse set of preclinical cancer models at a single dose. Our findings reveal that ZnCDA enhances tumour accumulation by disrupting endothelial cells in the tumour vasculature. ZnCDA preferentially targets tumour-associated macrophages to modulate antigen processing and presentation and subsequent priming of an anti-tumour T-cell response. ZnCDA reinvigorates the anti-tumour activity of both radiotherapy and immune checkpoint inhibitors in immunologically ‘cold’ pancreatic and glioma tumour models, offering a promising combination strategy for the treatment of intractable human cancers.","journal":"UNC Libraries","year":2024,"id":499638,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9493,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1348364,"name":"Weichselbaum R.R","orcid":null,"position":1,"is_corresponding":false},{"id":658476,"name":"Xinxin Huang","orcid":"0000-0002-4298-4859","position":2,"is_corresponding":false},{"id":1173291,"name":"Zhiyuan Xu","orcid":"0000-0001-6875-7171","position":3,"is_corresponding":false},{"id":146586,"name":"Wei Xing Zheng","orcid":"0000-0002-0572-5938","position":4,"is_corresponding":false},{"id":230828,"name":"Kun Yang","orcid":"0000-0002-2011-7084","position":5,"is_corresponding":false},{"id":1014824,"name":"András Piffkó","orcid":"0000-0001-5300-6594","position":6,"is_corresponding":false},{"id":638580,"name":"Jason Bugno","orcid":"0000-0002-3046-8072","position":7,"is_corresponding":false},{"id":1347561,"name":"Xinmin Fu","orcid":"0000-0002-9064-2626","position":8,"is_corresponding":false},{"id":1347562,"name":"Wanzun Lin","orcid":"0000-0003-3973-8849","position":9,"is_corresponding":false},{"id":258784,"name":"Jianlong Wang","orcid":"0000-0002-1317-6457","position":10,"is_corresponding":false},{"id":922697,"name":"Hua Liang","orcid":"0000-0003-3170-6922","position":11,"is_corresponding":false},{"id":681760,"name":"Ling Wang","orcid":"0000-0003-3220-6065","position":12,"is_corresponding":false},{"id":1347563,"name":"Wei Han","orcid":"0000-0002-8578-6780","position":13,"is_corresponding":false},{"id":1347564,"name":"Xiaoyu Jiang","orcid":"0009-0000-1706-7795","position":14,"is_corresponding":false},{"id":1347565,"name":"Shuai Li","orcid":"0000-0001-7585-018X","position":15,"is_corresponding":false},{"id":1348365,"name":"Ting J.P.Y","orcid":null,"position":16,"is_corresponding":false},{"id":1347560,"name":"Han Chen","orcid":"0000-0002-5912-3692","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T02:09:53.188165Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}