{"doi":"10.17615/m4d9-hm26","title":"General Health Status and Incidence of First-Onset Temporomandibular Disorder: The OPPERA Prospective Cohort Study","abstract":"Temporomandibular disorders (TMD) overlap with other health conditions but no study has examined which of these conditions increase the risk of developing first-onset TMD. The authors prospectively evaluated the relationship between health status at enrollment and subsequent incidence of TMD in 2,722 men and women. Participants aged 18–44 years had no history of TMD and were clinically free of TMD when enrolled in 2006–08 at four U.S. study sites in the OPPERA prospective cohort study. First-onset examiner-classified TMD developed in 260 people over a median 2.8 years of follow-up. Cox regression estimated the association between health conditions and TMD incidence while accounting for potential confounders. Incidence of first-onset TMD was 50% higher for people with lower back pain (adjusted hazard ratio [AHR] = 1.50, 95% confidence limits [95% CL]: 1.08, 2.10) and 75% higher for people with genital pain symptoms (AHR = 1.75 [95% CL: 1.04, 2.93]) than people without a history of these pain disorders. Digit ratio, a marker of intra-uterine exposure to sex hormones, was significantly associated with TMD incidence. Other independent predictors of first-onset TMD were sleep disturbance and cigarette smoking. These findings reveal multiple-influences of health status on incidence of first-onset TMD.","journal":"UNC Libraries","year":2020,"id":137393,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9456,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":301592,"name":"Roger B. Fillingim","orcid":"0000-0002-7699-8183","position":1,"is_corresponding":false},{"id":301594,"name":"Joel D. Greenspan","orcid":"0000-0003-4062-9797","position":2,"is_corresponding":false},{"id":301595,"name":"Anne E. Sanders","orcid":"0000-0003-2607-9514","position":3,"is_corresponding":false},{"id":301593,"name":"Richard Ohrbach","orcid":"0000-0002-9266-9734","position":4,"is_corresponding":false},{"id":301597,"name":"Gary D. Slade","orcid":"0000-0002-4065-6341","position":5,"is_corresponding":false},{"id":79748,"name":"Eric Bair","orcid":"0000-0001-8733-7869","position":6,"is_corresponding":false},{"id":276565,"name":"Ronald Dubner","orcid":null,"position":7,"is_corresponding":false},{"id":541052,"name":"Charles Knott","orcid":"0000-0002-3340-1850","position":8,"is_corresponding":false},{"id":130820,"name":"William Maixner","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:16:56.001887Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}