{"doi":"10.17615/kv3d-q618","title":"Curing HIV: Seeking to Target and Clear Persistent Infection","abstract":"Margolis and colleagues review progress and prospects toward developing a true cure for HIV-1 infection, focusing on the biological underpinnings of the “kick and kill” approach to curing HIV-1 infection, which couples reactivation of the latent, integrated provirus with immunotherapies to recognize and kill infected cells. © 2020 Elsevier Inc.Human immunodeficiency virus type 1 (HIV-1) infection persists despite years of antiretroviral therapy (ART). To remove the stigma and burden of chronic infection, approaches to eradicate or cure HIV infection are desired. Attempts to augment ART with therapies that reverse viral latency, paired with immunotherapies to clear infection, have advanced into the clinic, but the field is still in its infancy. We review foundational studies and highlight new insights in HIV cure research. Together with advances in ART delivery and HIV prevention strategies, future therapies that clear HIV infection may relieve society of the affliction of the HIV pandemic.","journal":"UNC Libraries","year":2020,"id":112659,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9614,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":533752,"name":"Joseph Eron","orcid":null,"position":1,"is_corresponding":false},{"id":249716,"name":"Nilu Goonetilleke","orcid":"0000-0003-2278-1656","position":2,"is_corresponding":false},{"id":456629,"name":"Richard Hafner","orcid":"0000-0002-3587-9559","position":3,"is_corresponding":false},{"id":533753,"name":"Ronald Swanstom","orcid":null,"position":4,"is_corresponding":false},{"id":233494,"name":"Nancie M. Archin","orcid":"0000-0002-7938-0389","position":5,"is_corresponding":false},{"id":249715,"name":"Cynthia L. Gay","orcid":"0000-0002-3620-3059","position":6,"is_corresponding":false},{"id":249714,"name":"Guido Ferrari","orcid":"0000-0001-7747-3349","position":7,"is_corresponding":false},{"id":533089,"name":"Juliana Garcia","orcid":"0000-0002-3435-577X","position":8,"is_corresponding":false},{"id":105520,"name":"David M. Margolis","orcid":"0000-0001-5714-0002","position":9,"is_corresponding":false},{"id":249712,"name":"Myron S. Cohen","orcid":"0000-0001-5917-9664","position":10,"is_corresponding":false},{"id":249717,"name":"Sarah Joseph","orcid":"0000-0001-9603-574X","position":11,"is_corresponding":false},{"id":249718,"name":"Anne‐Marie W. Turner","orcid":"0000-0002-7312-4616","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:13:17.845093Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}