{"doi":"10.17615/kc31-eq38","title":"Synthesis of novel spin-labeled derivatives of 5-FU as potential antineoplastic agents","abstract":"Chemotherapy is a general treatment option for various cancers, including lung cancer. In order to find compounds with superior bioactivity and less toxicity against lung cancer, novel spin-labeled 5-fluorouracil (5-FU) derivatives (3a–f) were synthesized and evaluated against four human tumor cell lines (A-549, DU-145, KB, and KBvin). Two promising compounds 3d and 3f exhibited IC50 values of 2.76 and 2.38 μM, respectively, against non-small cell lung carcinoma cell line A-549. These compounds were twofold more cytotoxic than 5-FU and less toxic against other tested cell lines. Compound 3f exhibited seven times more selective cytotoxicity against A-549 than 5-FU. Our results suggest that compounds 3d and 3f merit further investigation for development into clinical trial candidates for non-small cell lung cancer.","journal":"UNC Libraries","year":2020,"id":139253,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9515,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":594853,"name":"Xuan Tian","orcid":"0000-0003-1966-2445","position":1,"is_corresponding":false},{"id":244470,"name":"Susan L. Morris‐Natschke","orcid":"0000-0003-3772-0063","position":2,"is_corresponding":false},{"id":548269,"name":"Yang Liu","orcid":"0000-0001-7714-9194","position":3,"is_corresponding":false},{"id":602043,"name":"Zhijun Zhang","orcid":"0000-0003-3055-3426","position":4,"is_corresponding":false},{"id":548860,"name":"Chih-Ya Wang","orcid":null,"position":5,"is_corresponding":false},{"id":594854,"name":"Tian Jing","orcid":"0000-0001-9916-650X","position":6,"is_corresponding":false},{"id":548266,"name":"Meijuan Wang","orcid":"0000-0003-2579-8736","position":7,"is_corresponding":false},{"id":244475,"name":"Masuo Goto","orcid":"0000-0002-9659-1460","position":8,"is_corresponding":false},{"id":452494,"name":"Xiaoming Yang","orcid":"0000-0002-4076-3569","position":9,"is_corresponding":false},{"id":244473,"name":"Ying‐Qian Liu","orcid":"0000-0001-5040-2516","position":10,"is_corresponding":false},{"id":244476,"name":"Kuo‐Hsiung Lee","orcid":"0000-0002-6562-0070","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:17:10.185988Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}