{"doi":"10.17615/jxdm-1251","title":"Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer","abstract":"We report a comprehensive analysis of 412 muscle-invasive bladder cancers characterized by multiple TCGA analytical platforms. Fifty-eight genes were significantly mutated, and the overall mutational load was associated with APOBEC-signature mutagenesis. Clustering by mutation signature identified a high-mutation subset with 75% 5-year survival. mRNA expression clustering refined prior clustering analyses and identified a poor-survival “neuronal” subtype in which the majority of tumors lacked small cell or neuroendocrine histology. Clustering by mRNA, long non-coding RNA (lncRNA), and miRNA expression converged to identify subsets with differential epithelial-mesenchymal transition status, carcinoma in situ scores, histologic features, and survival. Our analyses identified 5 expression subtypes that may stratify response to different treatments. A multiplatform analysis of 412 muscle-invasive bladder cancer patients provides insights into mutational profiles with prognostic value and establishes a framework associating distinct tumor subtypes with clinical options.","journal":"UNC Libraries","year":2021,"id":230430,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7392,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":716114,"name":"G. Getz","orcid":null,"position":1,"is_corresponding":false},{"id":836889,"name":"M.A.A. Castro","orcid":null,"position":2,"is_corresponding":false},{"id":836890,"name":"L.J. Klimczak","orcid":null,"position":3,"is_corresponding":false},{"id":794621,"name":"J.N. Weinstein","orcid":null,"position":4,"is_corresponding":false},{"id":836891,"name":"Guanhong Guo","orcid":null,"position":5,"is_corresponding":false},{"id":590513,"name":"Chenyi Wu","orcid":"0009-0000-9537-124X","position":6,"is_corresponding":false},{"id":716130,"name":"T.M. Lichtenberg","orcid":null,"position":7,"is_corresponding":false},{"id":1721,"name":"G.B. Mills","orcid":null,"position":8,"is_corresponding":false},{"id":1870,"name":"Katherine A. Hoadley","orcid":"0000-0002-1216-477X","position":9,"is_corresponding":false},{"id":716131,"name":"K.M. Leraas","orcid":null,"position":10,"is_corresponding":false},{"id":836892,"name":"B. de Carvalho","orcid":null,"position":11,"is_corresponding":false},{"id":794641,"name":"R.S. Kanchi","orcid":null,"position":12,"is_corresponding":false},{"id":601005,"name":"Y. Lu","orcid":"0009-0003-1740-161X","position":13,"is_corresponding":false},{"id":26931,"name":"X. Su","orcid":"0000-0001-9155-3898","position":14,"is_corresponding":false},{"id":716116,"name":"V.E. Reuter","orcid":null,"position":15,"is_corresponding":false},{"id":794642,"name":"H. Al-Ahmadie","orcid":null,"position":16,"is_corresponding":false},{"id":794629,"name":"K.L. Mungall","orcid":null,"position":17,"is_corresponding":false},{"id":794649,"name":"S. Bullman","orcid":null,"position":18,"is_corresponding":false},{"id":697536,"name":"F. Sanchez-Vega","orcid":null,"position":19,"is_corresponding":false},{"id":697537,"name":"E.A. Gibb","orcid":null,"position":20,"is_corresponding":false},{"id":836893,"name":"B.A. Czerniak","orcid":null,"position":21,"is_corresponding":false},{"id":836894,"name":"D.J. McConkey","orcid":null,"position":22,"is_corresponding":false},{"id":697538,"name":"A.G. Robertson","orcid":null,"position":23,"is_corresponding":false},{"id":836895,"name":"S.P. Lerner","orcid":null,"position":24,"is_corresponding":false},{"id":202149,"name":"N. Schultz","orcid":null,"position":25,"is_corresponding":false},{"id":697531,"name":"TCGA Research Network","orcid":null,"position":26,"is_corresponding":false},{"id":836896,"name":"J. Bellmunt","orcid":null,"position":27,"is_corresponding":false},{"id":836897,"name":"C. Choo","orcid":null,"position":28,"is_corresponding":false},{"id":794639,"name":"C.S. Pedamallu","orcid":null,"position":29,"is_corresponding":false},{"id":591522,"name":"S.A. Shukla","orcid":null,"position":30,"is_corresponding":false},{"id":716108,"name":"P.W. Laird","orcid":null,"position":31,"is_corresponding":false},{"id":836898,"name":"D.A. Gordenin","orcid":null,"position":32,"is_corresponding":false},{"id":697557,"name":"R. Akbani","orcid":null,"position":33,"is_corresponding":false},{"id":356857,"name":"J. Kim","orcid":"0000-0002-5440-4057","position":34,"is_corresponding":false},{"id":794638,"name":"A.I. Ojesina","orcid":null,"position":35,"is_corresponding":false},{"id":396237,"name":"M. Meyerson","orcid":null,"position":36,"is_corresponding":false},{"id":624492,"name":"A.D. Cherniack","orcid":null,"position":37,"is_corresponding":false},{"id":836899,"name":"Jingyv Zhang","orcid":null,"position":38,"is_corresponding":false},{"id":697567,"name":"D.J. Kwiatkowski","orcid":null,"position":39,"is_corresponding":false},{"id":836900,"name":"V.S. Chagas","orcid":null,"position":40,"is_corresponding":false},{"id":794626,"name":"S. Sadeghi","orcid":null,"position":41,"is_corresponding":false},{"id":798729,"name":"T. Hinoue","orcid":null,"position":42,"is_corresponding":false},{"id":836888,"name":"D.E. Hansel","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:55:05.844766Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}