{"doi":"10.17615/jt8m-hw64","title":"A Two-stage Approach for Rapid Assessment of the Proportion Achieving Viral Suppression Using Routine Clinical Data","abstract":"Background: Improving viral suppression among people with HIV reduces morbidity, mortality, and transmission. Accordingly, monitoring the proportion of patients with a suppressed viral load is important to optimizing HIV care and treatment programs. But viral load data are often incomplete in clinical records. We illustrate a two-stage approach to estimate the proportion of treated people with HIV who have a suppressed viral load in the Dominican Republic. Methods: Routinely collected data on viral load and patient characteristics were recorded in a national database, but 74% of patients on treatment at the time of the study did not have a recent viral load measurement. We recruited a subset of these patients for a rapid assessment that obtained additional viral load measurements. We combined results from the rapid assessment and main database using a two-stage weighting approach and compared results to estimates obtained using standard approaches to account for missing data. Results: Of patients with recent routinely collected viral load data, 60% had a suppressed viral load. Results were similar after applying standard approaches to account for missing data. Using the two-stage approach, we estimated that 77% (95% confidence interval [CI] = 74, 80) of those on treatment had a suppressed viral load. Conclusions: When assessing the proportion of people on treatment with a suppressed viral load using routinely collected data, applying standard approaches to handle missing data may be inadequate. In these settings, augmenting routinely collected data with data collected through sampling-based approaches could allow more accurate and efficient monitoring of HIV treatment program effectiveness.","journal":"UNC Libraries","year":2023,"id":411078,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.948,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":34240,"name":"Scott J. Weir","orcid":"0000-0002-8020-434X","position":1,"is_corresponding":false},{"id":474122,"name":"J.K. Edwards","orcid":null,"position":2,"is_corresponding":false},{"id":1191533,"name":"S. Hileman","orcid":null,"position":3,"is_corresponding":false},{"id":590763,"name":"M.J. Seamans","orcid":null,"position":4,"is_corresponding":false},{"id":717512,"name":"Eliana Ramirez","orcid":null,"position":5,"is_corresponding":false},{"id":547227,"name":"Henry Gómez","orcid":"0000-0003-2660-1843","position":6,"is_corresponding":false},{"id":621144,"name":"Sabrina Zadrozny","orcid":"0000-0002-8811-8868","position":7,"is_corresponding":false},{"id":366444,"name":"Clare Barrington","orcid":"0000-0001-7802-4051","position":8,"is_corresponding":false},{"id":420010,"name":"Michael E. Herce","orcid":"0000-0002-3629-3867","position":9,"is_corresponding":false},{"id":432557,"name":"Yeycy Donastorg","orcid":"0000-0002-0556-0133","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:21:38.940853Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}