{"doi":"10.17615/jhrk-5742","title":"Congruence of patient- and clinician-reported toxicity in women receiving chemotherapy for early breast cancer","abstract":"Background: The National Cancer Institute's Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events, collected alongside the clinician-reported Common Terminology Criteria for Adverse Events, enables comparisons of patient and clinician reports on treatment toxicity. Methods: In a multisite study of women receiving chemotherapy for early-stage breast cancer, symptom reports were collected on the same day from patients and their clinicians for 17 symptoms; their data were not shared with each other. The proportions of moderate, severe, or very severe patient-reported symptom severity were compared with the proportions of clinician-rated grade 2, 3, or 4 toxicity. Patient-clinician agreement was assessed via κ statistics. Chi-square tests investigated whether patient characteristics were associated with patient-clinician agreement. Results: Among 267 women, the median age was 58 years (range, 24-83 years), and 26% were nonwhite. There was moderate scoring agreement (κ = 0.413-0.570) for 53% of symptoms, fair agreement for 41% (κ = 0.220-0.378), and slight agreement for 6% (κ = 0.188). For example, patient-reported and clinician-rated percentages were 22% and 8% for severe or very severe fatigue, 41% and 46% for moderate fatigue, 32% and 39% for mild fatigue, and 6% and 7% for none. Clinician severity scores were lower for nonwhite patients in comparison with white patients for peripheral neuropathy, nausea, arthralgia, and dyspnea. Conclusions: Although clinician reporting of symptoms is common practice in oncology, there is suboptimal agreement with the gold standard of patient self-reporting. These data provide further evidence supporting the integration of patient-reported outcomes into oncological clinical research and clinical practice to improve monitoring of symptoms as well as timely interventions for symptoms.","journal":"UNC Libraries","year":2021,"id":229886,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7335,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":803691,"name":"S.S. Shachar","orcid":null,"position":1,"is_corresponding":false},{"id":835136,"name":"E. Basch","orcid":null,"position":2,"is_corresponding":false},{"id":835137,"name":"J.C. Speca","orcid":null,"position":3,"is_corresponding":false},{"id":835138,"name":"R.E. Reinbolt","orcid":null,"position":4,"is_corresponding":false},{"id":175406,"name":"J.T. Lee","orcid":null,"position":5,"is_corresponding":false},{"id":613432,"name":"Y.T. Chen","orcid":null,"position":6,"is_corresponding":false},{"id":154166,"name":"J.H. Park","orcid":null,"position":7,"is_corresponding":false},{"id":835139,"name":"T.A. Jolly","orcid":null,"position":8,"is_corresponding":false},{"id":835140,"name":"W.A. Wood","orcid":null,"position":9,"is_corresponding":false},{"id":835141,"name":"B.B. Reeve","orcid":null,"position":10,"is_corresponding":false},{"id":835142,"name":"H.B. Muss","orcid":null,"position":11,"is_corresponding":false},{"id":803692,"name":"E.C. Dees","orcid":null,"position":12,"is_corresponding":false},{"id":835143,"name":"G.G. Kimmick","orcid":null,"position":13,"is_corresponding":false},{"id":835144,"name":"M.S. Karuturi","orcid":null,"position":14,"is_corresponding":false},{"id":801409,"name":"A.M. Deal","orcid":null,"position":15,"is_corresponding":false},{"id":835145,"name":"K.A. Nyrop","orcid":null,"position":16,"is_corresponding":false},{"id":755407,"name":"L.A. Carey","orcid":null,"position":17,"is_corresponding":false},{"id":801429,"name":"K.E. Reeder-Hayes","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:55:01.675482Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}