{"doi":"10.17615/jedj-tg46","title":"Unknown","abstract":null,"journal":null,"year":null,"id":640204,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Sequential phases of cortical specificationinvolve Neurogenin-dependentand -independent pathways","abstract":"Neocortical projection neurons, which segregate into six cortical layers according to their birthdate, have diverse morphologies, axonal projections and molecular profiles, yet they share a common cortical regional identity and glutamatergic neurotransmission phenotype. Here we demonstrate that distinct genetic programs operate at different stages of corticogenesis to specify the properties shared by all neocortical neurons. Ngn1 and Ngn2 are required to specify the cortical (regional), glutamatergic (neurotransmitter) and laminar (temporal) characters of early-born (lower-layer) neurons, while simultaneously repressing an alternative subcortical, GABAergic neuronal phenotype. Subsequently, later-born (upper-layer) cortical neurons are specified in an Ngn-independent manner, requiring instead the synergistic activities of Pax6 and Tlx, which also control a binary choice between cortical/glutamatergic and subcortical/GABAergic fates. Our study thus reveals an unanticipated heterogeneity in the genetic mechanisms specifying the identity of neocortical projection neurons.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19767382","pmcid":null,"openalex_id":"https://openalex.org/W2901674456","authors":[],"funders":[{"funder_name":"Canadian Institutes of Health Research","grant_id":"unidentified","title":"unidentified"}],"total_grants":1,"fwci":0.0,"citation_percentile":0.20570059,"influential_citations":0,"citation_trend":[],"oa_status":"green","license":"Springer Nature TDM","oa_locations":[{"url":"https://cdr.lib.unc.edu/downloads/9k41zn97w","host_type":"repository"},{"url":"https://doi.org/10.17615/jedj-tg46","host_type":"repository"},{"url":"https://epubs.surrey.ac.uk/849129/","host_type":""},{"url":"https://doi.org/10.1038/sj.emboj.7600278","host_type":""},{"url":"https://europepmc.org/articles/pmc514942?pdf=render","host_type":""},{"url":"https://dx.doi.org/10.17615/jedj-tg46","host_type":""},{"url":"https://pubmed.ncbi.nlm.nih.gov/15229646","host_type":""},{"url":"https://hal.science/hal-04137080v1","host_type":""},{"url":"https://dx.doi.org/10.1038/sj.emboj.7600278","host_type":""},{"url":"https://openresearch.surrey.ac.uk/esploro/outputs/journalArticle/Sequential-phases-of-cortical-specification-involve/99516668602346","host_type":""},{"url":"https://doi.org/https://doi.org/10.1038/sj.emboj.7600278","host_type":""}],"fields_of_study":["Neurobiology and Insect Physiology Research","Receptor Mechanisms and Signaling","Neuroscience and Neuropharmacology Research","0301 basic medicine","03 medical and health sciences","0303 health sciences"],"mesh_terms":[],"keywords":["Corticogenesis","Glutamatergic","Neuroscience","GABAergic","Biology","Phenotype","Cortex (anatomy)","Cerebral cortex","Neocortex","Glutamate receptor","Inhibitory postsynaptic potential","Gene","Embryonic stem cell","Receptor","Genetics","Basic Helix-Loop-Helix Proteins","571","neurotransmitter phenotype","PAX6 Transcription Factor","Protein Array Analysis","Receptors, Cytoplasmic and Nuclear","Mice, Transgenic","Nerve Tissue Proteins","[SDV.GEN] Life Sciences [q-bio]/Genetics","Mice","laminar specification","Animals","Paired Box Transcription Factors","Eye Proteins","Homeodomain Proteins","Mice, Knockout","Neurons","[SDV.GEN]Life Sciences [q-bio]/Genetics","Gene Expression Profiling","Gene Expression Regulation, Developmental","Mice, Mutant Strains","Repressor Proteins","Neurogenins","Mutation","Transcription Factors"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-07T07:54:37.215798Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}