{"doi":"10.17615/jcyr-9v75","title":"Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas","abstract":"Sarcomas are a broad family of mesenchymal malignancies exhibiting remarkable histologic diversity. We describe the multi-platform molecular landscape of 206 adult soft tissue sarcomas representing 6 major types. Along with novel insights into the biology of individual sarcoma types, we report three overarching findings: (1) unlike most epithelial malignancies, these sarcomas (excepting synovial sarcoma) are characterized predominantly by copy-number changes, with low mutational loads and only a few genes (, , ) highly recurrently mutated across sarcoma types; (2) within sarcoma types, genomic and regulomic diversity of driver pathways defines molecular subtypes associated with patient outcome; and (3) the immune microenvironment, inferred from DNA methylation and mRNA profiles, associates with outcome and may inform clinical trials of immune checkpoint inhibitors. Overall, this large-scale analysis reveals previously unappreciated sarcoma-type-specific changes in copy number, methylation, RNA, and protein, providing insights into refining sarcoma therapy and relationships to other cancer types.","journal":"UNC Libraries","year":2020,"id":78414,"datarank":0.44166584687496613,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"self_citation_contribution":0.44166584687496613,"citation_network_contribution":0.0,"self_endowment_contribution":0.44166584687496613,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.913,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":408409,"name":"Candace Shelton","orcid":null,"position":1,"is_corresponding":false},{"id":107871,"name":"Matthew Meyerson","orcid":"0000-0002-9133-8108","position":2,"is_corresponding":false},{"id":407702,"name":"Carrie Cibulskis","orcid":"0000-0002-1996-8957","position":3,"is_corresponding":false},{"id":407703,"name":"Jia Liu","orcid":"0000-0003-0490-5109","position":4,"is_corresponding":false},{"id":13218,"name":"Joshua Armenia","orcid":"0000-0002-9005-7769","position":5,"is_corresponding":false},{"id":14257,"name":"Christina Yau","orcid":"0000-0002-1937-0859","position":6,"is_corresponding":false},{"id":13771,"name":"Dennis T. Maglinte","orcid":"0000-0001-8903-0836","position":7,"is_corresponding":false},{"id":1918,"name":"Rehan Akbani","orcid":"0000-0003-2686-7721","position":8,"is_corresponding":false},{"id":1839,"name":"David Van Den Berg","orcid":"0000-0002-5404-5218","position":9,"is_corresponding":false},{"id":1863,"name":"Nikolaus Schultz","orcid":"0000-0002-0131-4904","position":10,"is_corresponding":false},{"id":32891,"name":"Matthew L. Anderson","orcid":"0000-0002-2081-4672","position":11,"is_corresponding":false},{"id":70158,"name":"Armaz Mariamidze","orcid":"0000-0002-9775-6116","position":12,"is_corresponding":false},{"id":1719,"name":"Beth Y. Karlan","orcid":"0000-0002-9451-2933","position":13,"is_corresponding":false},{"id":407704,"name":"Amie Radenbaugh","orcid":"0000-0001-7147-1094","position":14,"is_corresponding":false},{"id":69751,"name":"Eric Thompson","orcid":"0000-0001-7144-9735","position":15,"is_corresponding":false},{"id":1916,"name":"Matthew D. Wilkerson","orcid":"0000-0003-2727-0230","position":16,"is_corresponding":false},{"id":407705,"name":"Qiang Sun","orcid":"0000-0002-5342-0637","position":17,"is_corresponding":false},{"id":14435,"name":"Francisco Sánchez-Vega","orcid":"0000-0002-2990-4893","position":18,"is_corresponding":false},{"id":13860,"name":"Yulia Newton","orcid":"0000-0002-6874-4335","position":19,"is_corresponding":false},{"id":69892,"name":"Teniola Akeredolu","orcid":null,"position":20,"is_corresponding":false},{"id":14273,"name":"Jean C. Zenklusen","orcid":"0000-0002-9489-1873","position":21,"is_corresponding":false},{"id":309158,"name":"Davis R. Ingram","orcid":"0000-0001-5967-1501","position":22,"is_corresponding":false},{"id":13213,"name":"Elizabeth L. Appelbaum","orcid":null,"position":23,"is_corresponding":false},{"id":69837,"name":"Madhusmita Behera","orcid":"0000-0003-1121-6002","position":24,"is_corresponding":false},{"id":69792,"name":"Chandrajit P. Raut","orcid":"0000-0001-7297-3221","position":25,"is_corresponding":false},{"id":407706,"name":"Ye Wu","orcid":"0000-0001-8978-3483","position":26,"is_corresponding":false},{"id":13804,"name":"Shaowu Meng","orcid":null,"position":27,"is_corresponding":false},{"id":408410,"name":"Phil DiSaia","orcid":null,"position":28,"is_corresponding":false},{"id":244417,"name":"Richard F. Riedel","orcid":"0000-0001-5412-8710","position":29,"is_corresponding":false},{"id":14445,"name":"Tara Skelly","orcid":null,"position":30,"is_corresponding":false},{"id":69756,"name":"Tara M. Lichtenberg","orcid":"0000-0003-4081-8854","position":31,"is_corresponding":false},{"id":70104,"name":"Clement Adebamowo","orcid":"0000-0002-6571-2880","position":32,"is_corresponding":false},{"id":14072,"name":"Heidi J. Sofia","orcid":"0000-0002-4990-5877","position":33,"is_corresponding":false},{"id":408411,"name":"Carmen Helsel","orcid":null,"position":34,"is_corresponding":false},{"id":34868,"name":"Matt van de Rijn","orcid":"0000-0002-1909-9739","position":35,"is_corresponding":false},{"id":13378,"name":"Erin Curley","orcid":null,"position":36,"is_corresponding":false},{"id":13344,"name":"Andrew D. Cherniack","orcid":"0000-0003-0470-0111","position":37,"is_corresponding":false},{"id":69701,"name":"Rashi Naresh","orcid":null,"position":38,"is_corresponding":false},{"id":288716,"name":"Fanny Dao","orcid":"0000-0001-5285-6044","position":39,"is_corresponding":false},{"id":279356,"name":"Peter W. Laird","orcid":"0000-0001-9117-3641","position":40,"is_corresponding":false},{"id":13598,"name":"Michael Ittmann","orcid":"0000-0003-4802-0978","position":41,"is_corresponding":false},{"id":34241,"name":"Andrew K. Godwin","orcid":"0000-0002-3987-9580","position":42,"is_corresponding":false},{"id":13711,"name":"Darlene Lee","orcid":null,"position":43,"is_corresponding":false},{"id":377719,"name":"Heather K. Schmidt","orcid":null,"position":44,"is_corresponding":false},{"id":241966,"name":"Chris Sander","orcid":"0000-0001-6059-6270","position":45,"is_corresponding":false},{"id":13753,"name":"Yiling Lu","orcid":"0000-0002-3662-2106","position":46,"is_corresponding":false},{"id":407707,"name":"Jaegil Kim","orcid":"0000-0003-4588-5618","position":47,"is_corresponding":false},{"id":18423,"name":"Matthew A. Wyczalkowski","orcid":"0000-0003-4197-551X","position":48,"is_corresponding":false},{"id":13369,"name":"Matthew G. Cordes","orcid":null,"position":49,"is_corresponding":false},{"id":408412,"name":"Lisle E. Mose","orcid":null,"position":50,"is_corresponding":false},{"id":1943,"name":"Martin L. Ferguson","orcid":"0000-0002-2050-4199","position":51,"is_corresponding":false},{"id":13479,"name":"Nils Gehlenborg","orcid":"0000-0003-0327-8297","position":52,"is_corresponding":false},{"id":32006,"name":"Roel G.W. Verhaak","orcid":"0000-0003-2773-0436","position":53,"is_corresponding":false},{"id":407708,"name":"Mei Huang","orcid":"0000-0002-5766-0718","position":54,"is_corresponding":false},{"id":250654,"name":"Pan Tong","orcid":"0000-0002-8475-4437","position":55,"is_corresponding":false},{"id":13902,"name":"Joel S. Parker","orcid":"0000-0003-2080-6901","position":56,"is_corresponding":false},{"id":13808,"name":"Piotr A. Mieczkowski","orcid":"0000-0003-2418-0096","position":57,"is_corresponding":false},{"id":69849,"name":"Gabriel Sica","orcid":null,"position":58,"is_corresponding":false},{"id":407709,"name":"Yan Shi","orcid":"0000-0003-4119-3702","position":59,"is_corresponding":false},{"id":13231,"name":"Miruna Balasundaram","orcid":null,"position":60,"is_corresponding":false},{"id":300361,"name":"Reanne Bowlby","orcid":null,"position":61,"is_corresponding":false},{"id":69699,"name":"Sudha Chudamani","orcid":null,"position":62,"is_corresponding":false},{"id":408413,"name":"Bootwalla, Moiz S.","orcid":null,"position":63,"is_corresponding":false},{"id":13784,"name":"Marco A. Marra","orcid":"0000-0001-7146-7175","position":64,"is_corresponding":false},{"id":408414,"name":"Janae V. Simons","orcid":null,"position":65,"is_corresponding":false},{"id":1720,"name":"Douglas A. Levine","orcid":"0000-0003-1038-8232","position":66,"is_corresponding":false},{"id":258143,"name":"Esther Drill","orcid":"0000-0002-3315-4538","position":67,"is_corresponding":false},{"id":70103,"name":"Rashna Madan","orcid":null,"position":68,"is_corresponding":false},{"id":407710,"name":"John Wrangle","orcid":"0000-0001-8998-4509","position":69,"is_corresponding":false},{"id":13967,"name":"Jeffrey Roach","orcid":"0000-0001-9817-5877","position":70,"is_corresponding":false},{"id":407711,"name":"А. И. Карселадзе","orcid":"0000-0003-0524-6918","position":71,"is_corresponding":false},{"id":228165,"name":"Jing Wang","orcid":"0000-0002-5398-0802","position":72,"is_corresponding":false},{"id":407712,"name":"J. Novak","orcid":"0000-0001-5766-0577","position":73,"is_corresponding":false},{"id":234743,"name":"Lynda Chin","orcid":null,"position":74,"is_corresponding":false},{"id":20530,"name":" Jeff Boyd ","orcid":"0000-0002-3517-7637","position":75,"is_corresponding":false},{"id":408415,"name":"Konstantin Fedosenko","orcid":null,"position":76,"is_corresponding":false},{"id":407713,"name":"Keila E. Torres","orcid":"0000-0002-1855-0989","position":77,"is_corresponding":false},{"id":13836,"name":"Karen Mungall","orcid":"0000-0002-9092-4391","position":78,"is_corresponding":false},{"id":13955,"name":"W. Kimryn Rathmell","orcid":"0000-0002-4984-0225","position":79,"is_corresponding":false},{"id":1768,"name":"Michael D. McLellan","orcid":"0000-0002-2703-8784","position":80,"is_corresponding":false},{"id":14066,"name":"Payal Sipahimalani","orcid":null,"position":81,"is_corresponding":false},{"id":228163,"name":"Lixia Diao","orcid":"0000-0001-6995-4492","position":82,"is_corresponding":false},{"id":1883,"name":"Charles M. Perou","orcid":"0000-0001-9827-2247","position":83,"is_corresponding":false},{"id":407714,"name":"Georgy M. Manikhas","orcid":"0000-0002-2569-1683","position":84,"is_corresponding":false},{"id":247604,"name":"Carl M. Gay","orcid":"0000-0002-4907-0718","position":85,"is_corresponding":false},{"id":13129,"name":"Eric Minwei Liu","orcid":"0000-0002-3594-6678","position":86,"is_corresponding":false},{"id":1398,"name":"Rameen Beroukhim","orcid":"0000-0001-6303-3609","position":87,"is_corresponding":false},{"id":408416,"name":"Tom Bodenheimer","orcid":null,"position":88,"is_corresponding":false},{"id":14218,"name":"Winghing Wong","orcid":"0000-0003-2494-1721","position":89,"is_corresponding":false},{"id":13545,"name":"David I. Heiman","orcid":"0000-0001-7895-4259","position":90,"is_corresponding":false},{"id":408417,"name":"David Mallery","orcid":null,"position":91,"is_corresponding":false},{"id":407715,"name":"John Bartlett","orcid":"0000-0001-9529-6198","position":92,"is_corresponding":false},{"id":33537,"name":"Jenny Lester","orcid":"0000-0003-4914-3275","position":93,"is_corresponding":false},{"id":407716,"name":"David A. Gutman","orcid":"0000-0002-1386-8701","position":94,"is_corresponding":false},{"id":79467,"name":"Suresh S. Ramalingam","orcid":"0000-0002-0757-3106","position":95,"is_corresponding":false},{"id":13224,"name":"J. Todd Auman","orcid":null,"position":96,"is_corresponding":false},{"id":34409,"name":"Venkata Yellapantula","orcid":"0000-0001-9848-3263","position":97,"is_corresponding":false},{"id":69772,"name":"Jennifer Eschbacher","orcid":"0000-0002-2599-0819","position":98,"is_corresponding":false},{"id":69753,"name":"Julie M. Gastier-Foster","orcid":null,"position":99,"is_corresponding":false},{"id":1834,"name":"Daniel J. Weisenberger","orcid":"0000-0001-8303-2603","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T21:49:40.769098Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}