{"doi":"10.17615/j1b8-vy05","title":"Editorial: The role of adipose tissue and resident immune cells in infections","abstract":"Adipose tissues are distributed throughout the body and are in direct contact with sites of infection entry, such as mucosal tissues, gut, and skin. There is increasing appreciation that adipose tissue can influence local and systemic immune responses to infection. The adipose tissue can modulate immune responses through changes in the expression of pro- and anti-inflammatory cytokines, adipokines, and hormones that regulate general metabolism. Immune cells within adipose show differentiation states that are distinct from those in circulation or in lymphoid tissues, suggesting that the adipose environment regulates immune cell activity. The mechanisms leading to immune cell recruitment and maintenance within adipose remain enigmatic. Changes in diet that lead to obesity can alter the frequencies of regulatory or effector cells within adipose, potentially affecting local and systemic immune protection. Obesity is associated with higher susceptibility to infections possibly due to alterations in immune cells residing in adipose tissue. The interplay between immune cells and adipose is complex and bi-directional: immune cells residing within adipose tissue can perturb adipose tissue homeostasis and whole-body metabolism and, conversely, metabolic cues can modulate immune responses. Several reports demonstrate that microorganisms can target and even persist in adipose tissues. However, relatively few studies have addressed the immunological consequences of adipose tissue infection.","journal":"UNC Libraries","year":2024,"id":498957,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9544,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":275085,"name":"Jason K. Whitmire","orcid":"0000-0003-2578-6073","position":1,"is_corresponding":false},{"id":871229,"name":"Christine Bourgeois","orcid":"0000-0003-1146-6087","position":2,"is_corresponding":false},{"id":1330499,"name":"Luzia Teixeira","orcid":"0000-0001-5424-2345","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T02:09:45.971055Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}