{"doi":"10.17615/gvch-5517","title":"Gene-by-psychosocial factor interactions influence diastolic blood pressure in european and african ancestry populations: Meta-analysis of four cohort studies","abstract":"Inter-individual variability in blood pressure (BP) is influenced by both genetic and nongenetic factors including socioeconomic and psychosocial stressors. A deeper understanding of the gene-by-socioeconomic/psychosocial factor interactions on BP may help to identify individuals that are genetically susceptible to high BP in specific social contexts. In this study, we used a genomic region-based method for longitudinal analysis, Longitudinal Gene-Environment-Wide Interaction Studies (LGEWIS), to evaluate the effects of interactions between known socioeconomic/ psychosocial and genetic risk factors on systolic and diastolic BP in four large epidemiologic cohorts of European and/or African ancestry. After correction for multiple testing, two interactions were significantly associated with diastolic BP. In European ancestry participants, outward/trait anger score had a significant interaction with the C10orf107 genomic region (p = 0.0019). In African ancestry participants, depressive symptom score had a significant interaction with the HFE genomic region (p = 0.0048). This study provides a foundation for using genomic region-based longitudinal analysis to identify subgroups of the population that may be at greater risk of elevated BP due to the combined influence of genetic and socioeconomic/psychosocial risk factors.","journal":"UNC Libraries","year":2024,"id":499106,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9552,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":431554,"name":"E. Boerwinkle","orcid":null,"position":1,"is_corresponding":false},{"id":1346972,"name":"K Yasutake","orcid":null,"position":2,"is_corresponding":false},{"id":941183,"name":"Stanford Mwasongwe","orcid":"0000-0001-7812-1599","position":3,"is_corresponding":false},{"id":251225,"name":"Mario Sims","orcid":"0000-0002-2554-8932","position":4,"is_corresponding":false},{"id":22017,"name":"Yan V. Sun","orcid":"0000-0002-2838-1824","position":5,"is_corresponding":false},{"id":1346973,"name":"B.L. Needham","orcid":null,"position":6,"is_corresponding":false},{"id":14675,"name":"Wei Zhao","orcid":"0000-0001-7388-0692","position":7,"is_corresponding":false},{"id":1346943,"name":"D.R. Weir","orcid":null,"position":8,"is_corresponding":false},{"id":553491,"name":"Yan Gao","orcid":"0000-0002-2901-6933","position":9,"is_corresponding":false},{"id":706018,"name":"J.A. Smith","orcid":null,"position":10,"is_corresponding":false},{"id":1346974,"name":"C. August","orcid":null,"position":11,"is_corresponding":false},{"id":251227,"name":"Ana V. Diez Roux","orcid":"0000-0001-9658-7050","position":12,"is_corresponding":false},{"id":532405,"name":"G. Heiss","orcid":null,"position":13,"is_corresponding":false},{"id":591598,"name":"S.L.R. Kardia","orcid":null,"position":14,"is_corresponding":false},{"id":90099,"name":"Michael Griswold","orcid":"0000-0001-8106-5516","position":15,"is_corresponding":false},{"id":232154,"name":"Arnab Chakravarti","orcid":"0000-0002-5392-8721","position":16,"is_corresponding":false},{"id":400580,"name":"Scott M. Ratliff","orcid":"0000-0002-6109-662X","position":17,"is_corresponding":false},{"id":803301,"name":"A.C. Morrison","orcid":null,"position":18,"is_corresponding":false},{"id":835488,"name":"J.D. Faul","orcid":null,"position":19,"is_corresponding":false},{"id":837646,"name":"S.K. Musani","orcid":null,"position":20,"is_corresponding":false},{"id":743374,"name":"Karen Rose","orcid":"0000-0001-7382-3671","position":21,"is_corresponding":false},{"id":526071,"name":"K.E. North","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:09:45.971055Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}