{"doi":"10.17615/gc4e-8v84","title":"Attenuation of Acute Graft-versus-Host Disease in the Absence of the Transcription Factor ROR t","abstract":"Graft-versus-host disease (GvHD) remains the most significant complication after allogeneic stem cell transplantation (allo-SCT). Previously, acute GvHD had been considered to be mediated predominantly by Th1 polarized T cells. Recently, investigators have identified a second pro-inflammatory lineage of T cells termed Th17 that is critically dependent on the transcription factor RORγt. Here, we have evaluated the role of Th17 cells in murine acute GvHD by infusing donor T cells lacking RORC and as a consequence the isoform RORγt. Recipients given donor CD4+ and CD8+ T cells lacking RORC had significantly attenuated acute GvHD and markedly decreased tissue pathology in the colon, liver, and lung. Using a clinically relevant haploidentical murine transplantation model, we showed that RORC−/− CD4+ T cells alone diminished the severity and lethality of aGvHD. This was not found when CD4+ T cells from RORC−/− mice were given to completely mismatched BALB/c mice, and correlated with absolute differences in the generation of TNF in the colon post transplant. Thus, CD4+ T cell expression of RORC is important in the pathogenesis of acute GVHD.","journal":"UNC Libraries","year":2020,"id":137967,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9522,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":90201,"name":"Dan R. Littman","orcid":"0000-0002-2850-8688","position":1,"is_corresponding":false},{"id":52067,"name":"Bruce R. Blazar","orcid":"0000-0002-9608-9841","position":2,"is_corresponding":false},{"id":262408,"name":"Jonathan S. Serody","orcid":"0000-0003-4568-1092","position":3,"is_corresponding":false},{"id":598603,"name":"Michelle L. West","orcid":"0000-0003-1080-8452","position":4,"is_corresponding":false},{"id":599335,"name":"Michael Carlson","orcid":null,"position":5,"is_corresponding":false},{"id":533107,"name":"James M. Coghill","orcid":"0000-0002-4736-0877","position":6,"is_corresponding":false},{"id":599336,"name":"Le Shara M. Fulton","orcid":null,"position":7,"is_corresponding":false},{"id":488197,"name":"Angela Panoskaltsis‐Mortari","orcid":"0000-0003-1802-1785","position":8,"is_corresponding":false},{"id":527253,"name":"Laura E. Ott","orcid":"0000-0002-9645-7608","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:16:59.449905Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}