{"doi":"10.17615/g8ag-0v51","title":"Infection and depletion of CD4+group-1 innate lymphoid cells by HIV-1 via type-I interferon pathway","abstract":"Innate lymphoid cells (ILCs) are severely depleted during chronic HIV-1 infection by unclear mechanisms. We report here that human ILC1s comprising of CD4+and CD4-subpopulations were present in various human lymphoid organs but with different transcription programs and functions. Importantly, CD4+ILC1s expressed HIV-1 co-receptors and were productively infected by HIV-1 in vitro and in vivo. Furthermore, chronic HIV-1 infection activated and depleted both CD4+and CD4-ILC1s, and impaired their cytokine production activity. Highly active antiretroviral (HAART) therapy in HIV-1 patients efficiently rescued the ILC1 numbers and reduced their activation, but failed to restore their functionality. We also found that blocking type-I interferon (IFN-I) signaling during HIV-1 infection in vivo in humanized mice prevented HIV-1 induced depletion or apoptosis of ILC1 cells. Therefore, we have identified the CD4+ILC1 cells as a new target population for HIV-1 infection, and revealed that IFN-I contributes to the depletion of ILC1s during HIV-1 infection.","journal":"UNC Libraries","year":2020,"id":116049,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9543,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":398077,"name":"Haisheng Yu","orcid":"0000-0002-1757-1411","position":1,"is_corresponding":false},{"id":237871,"name":"Xin Zhang","orcid":"0000-0001-9751-7054","position":2,"is_corresponding":false},{"id":243366,"name":"Hongbo Wang","orcid":"0000-0001-8530-2339","position":3,"is_corresponding":false},{"id":543670,"name":"ligup Zhang","orcid":null,"position":4,"is_corresponding":false},{"id":542894,"name":"Qiang Fu","orcid":"0000-0002-5191-3315","position":5,"is_corresponding":false},{"id":542895,"name":"Zhenwen Liu","orcid":"0000-0001-9397-2260","position":6,"is_corresponding":false},{"id":537946,"name":"Zheng Zhang","orcid":"0000-0002-3544-1389","position":7,"is_corresponding":false},{"id":538457,"name":"Bo Tu","orcid":null,"position":8,"is_corresponding":false},{"id":537948,"name":"Juanjuan Zhao","orcid":"0000-0003-1002-9272","position":9,"is_corresponding":false},{"id":255662,"name":"Lishan Su","orcid":"0000-0002-0350-5560","position":10,"is_corresponding":false},{"id":537939,"name":"Guangming Li","orcid":"0000-0003-2286-7679","position":11,"is_corresponding":false},{"id":307818,"name":"Qi Wang","orcid":"0000-0002-5287-6050","position":12,"is_corresponding":false},{"id":543671,"name":"Yanling Sun","orcid":null,"position":13,"is_corresponding":false},{"id":537938,"name":"Liang Cheng","orcid":"0000-0001-6049-5293","position":14,"is_corresponding":false},{"id":367443,"name":"Weiwei Chen","orcid":"0000-0003-1674-3231","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:13:40.596604Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}