{"doi":"10.17615/g87x-sy30","title":"Associations between SLC16A11 variants and diabetes in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)","abstract":"Five sequence variants in SLC16A11 (rs117767867, rs13342692, rs13342232, rs75418188, and rs75493593), which occur in two non-reference haplotypes, were recently shown to be associated with diabetes in Mexicans from the SIGMA consortium. We aimed to determine whether these previous findings would replicate in the HCHS/SOL Mexican origin group and whether genotypic effects were similar in other HCHS/SOL groups. We analyzed these five variants in 2492 diabetes cases and 5236 controls from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), which includes U.S. participants from six diverse background groups (Mainland groups: Mexican, Central American, and South American; and Caribbean groups: Puerto Rican, Cuban, and Dominican). We estimated the SNP-diabetes association in the six groups and in the combined sample. We found that the risk alleles occur in two non-reference haplotypes in HCHS/SOL, as in the SIGMA Mexicans. The haplotype frequencies were very similar between SIGMA Mexicans and the HCHS/SOL Mainland groups, but different in the Caribbean groups. The SLC16A11 sequence variants were significantly associated with risk for diabetes in the Mexican origin group (P = 0.025), replicating the SIGMA findings. However, these variants were not significantly associated with diabetes in a combined analysis of all groups, although the power to detect such effects was 85% (assuming homogeneity of effects among the groups). Additional analyses performed separately in each of the five non-Mexican origin groups were not significant. We also analyzed (1) exclusion of young controls and, (2) SNP by BMI interactions, but neither was significant in the HCHS/SOL data. The previously reported effects of SLC16A11 variants on diabetes in Mexican samples was replicated in a large Mexican-American sample, but these effects were not significant in five non-Mexican Hispanic/Latino groups sampled from U.S. populations. Lack of replication in the HCHS/SOL non-Mexicans, and in the entire HCHS/SOL sample combined may represent underlying genetic heterogeneity. These results indicate a need for future genetic research to consider heterogeneity of the Hispanic/Latino population in the assessment of disease risk, but add to the evidence suggesting SLC16A11 as a potential therapeutic target for type 2 diabetes.","journal":"UNC Libraries","year":2024,"id":499119,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9448,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1346999,"name":"M.L. Avilés-Santa","orcid":null,"position":1,"is_corresponding":false},{"id":526168,"name":"Q. Qi","orcid":null,"position":2,"is_corresponding":false},{"id":538413,"name":"J.I. Rotter","orcid":null,"position":3,"is_corresponding":false},{"id":591546,"name":"Y.-D.I. Chen","orcid":null,"position":4,"is_corresponding":false},{"id":24765,"name":"Bertha Hidalgo","orcid":"0000-0002-2556-1969","position":5,"is_corresponding":false},{"id":431554,"name":"E. Boerwinkle","orcid":null,"position":6,"is_corresponding":false},{"id":1346191,"name":"J. Cai","orcid":"0000-0003-0477-6335","position":7,"is_corresponding":false},{"id":526071,"name":"K.E. North","orcid":null,"position":8,"is_corresponding":false},{"id":25023,"name":"Adam A. Szpiro","orcid":"0000-0003-4995-238X","position":9,"is_corresponding":false},{"id":1314684,"name":"A.M. Stilp","orcid":null,"position":10,"is_corresponding":false},{"id":21964,"name":"Robert C. Kaplan","orcid":"0000-0003-1571-4615","position":11,"is_corresponding":false},{"id":591153,"name":"N. Schneiderman","orcid":null,"position":12,"is_corresponding":false},{"id":57755,"name":"T. Sofer","orcid":null,"position":13,"is_corresponding":false},{"id":980420,"name":"C.C. Laurie","orcid":null,"position":14,"is_corresponding":false},{"id":538012,"name":"Bing Yu","orcid":"0000-0001-6605-6742","position":15,"is_corresponding":false},{"id":540980,"name":"George Papanicolaou","orcid":"0000-0003-4876-7457","position":16,"is_corresponding":false},{"id":591578,"name":"D.K. Arnett","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:09:45.971055Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}