{"doi":"10.17615/g4k4-mk75","title":"Quantitation of Pretreatment Serum IP-10 Improves the Predictive Value of an IL28B Gene Polymorphism for Hepatitis C Treatment Response","abstract":"Polymorphisms of IL28B gene are highly associated with sustained virological response (SVR) in patients with chronic hepatitis C treated with peginterferon and ribavirin. Quantitation of Interferon-γ Inducible Protein-10 (IP-10) may also differentiate antiviral response. We evaluated IP-10 levels in pretreatment serum from 115 non-responders and 157 sustained responders in the VIRAHEP-C cohort, including African Americans (AA) and Caucasian Americans (CA). Mean IP-10 was lower in sustained responders compared to non-responders (460 ± 37 pg/ml vs 697 ± 49 pg/ml, p<0.001), both in AA and CA. The positive predictive value of low IP-10 levels (<600 pg/ml) for SVR was 69% while the negative predictive value of high IP-10 levels (>600 pg/ml) was 67%. We assessed the combination of pretreatment IP-10 levels with IL28B genotype as predictors of treatment response. The IL28B polymorphism rs12979860 was tested in 210 participants. CC, CT, or TT genotypes were found in 30%, 49%, and 21%, respectively, with corresponding SVR rates of 87%, 50%, and 39% (p<0.0001). Serum IP-10 levels within the IL28B genotype groups provided additional information regarding the likelihood of SVR (p< 0.0001). CT carriers with low IP-10 had 64% SVR versus 24% with high IP-10. Similarly, a higher SVR rate was identified for TT and CC carriers with low versus high IP-10 (TT: 48% versus 20%, CC: 89% versus 79%). IL28B genotype and baseline IP-10 levels were additive but independent when predicting SVR in both AA and CA.","journal":"UNC Libraries","year":2020,"id":115194,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9477,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":529632,"name":"Jama M. Darling","orcid":null,"position":1,"is_corresponding":false},{"id":541376,"name":"Gregory Fanning","orcid":null,"position":2,"is_corresponding":false},{"id":541377,"name":"Mieke De Wit","orcid":null,"position":3,"is_corresponding":false},{"id":63771,"name":"Kevin V. Shianna","orcid":null,"position":4,"is_corresponding":false},{"id":540799,"name":"Nezam H. Afdhal","orcid":"0000-0002-7342-6593","position":5,"is_corresponding":false},{"id":541378,"name":"Annick Scholliers","orcid":null,"position":6,"is_corresponding":false},{"id":541379,"name":"Jacques Bollekens","orcid":null,"position":7,"is_corresponding":false},{"id":40952,"name":"Michael Fried","orcid":null,"position":8,"is_corresponding":false},{"id":30756,"name":"David B. Goldstein","orcid":"0000-0002-1111-2820","position":9,"is_corresponding":false},{"id":540800,"name":"Alexander Thompson","orcid":"0000-0001-9882-0071","position":10,"is_corresponding":false},{"id":540801,"name":"Charles D. Howell","orcid":"0000-0003-1188-0130","position":11,"is_corresponding":false},{"id":33066,"name":"John G. McHutchison","orcid":null,"position":12,"is_corresponding":false},{"id":541380,"name":"Michael L. Hudson","orcid":null,"position":13,"is_corresponding":false},{"id":540802,"name":"Willem Talloen","orcid":"0000-0003-1762-5755","position":14,"is_corresponding":false},{"id":540798,"name":"Jeroen Aerssens","orcid":"0000-0002-9254-4800","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:13:36.820928Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}